Biobehavioral mechanisms underlying reacitve aggression in BPD: Validation and pharmacological modulation

BPD 反应性攻击的生物行为机制：验证和药理学调节

• 批准号: 276000380
• 负责人: Professorin Dr. Katja Bertsch, Ph.D.
• 金额: --
• 依托单位: Klinik für Allgemeine Psychiatrie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/276000380?language=en
• 关键词: Biobehavioral; mechanisms; underlying; reacitve; aggression

Aggression emerges as a key feature of borderline BPD. Despite the high prevalence and individual as well as social costs caused by aggression, the neurobiological and behavioral (henceforth called biobehavioral) mechanisms of aggression in BPD remain unclear, and empirically founded, targeted, and cost-effective interventions that reduce aggression in BPD are still lacking. Based on the results of the first funding period and previous studies, we have recently proposed five biobehavioral mechanisms which mediate aggression in BPD, comprising: threat hypersensitivity, maladaptive anger regulation, approach rather than avoidance of social threat cues, deficits in cognitive empathy, and enhanced emotional contagion. The current project aims to 1) investigate the validity, i.e., the predictive power of these five previously identified biobehavioral mechanisms to predict aggression in BPD. Aggression will be experimentally provoked and measured using a new MRI-compatible modification of the wellestablished Taylor Aggression Paradigm, which mimics real-life social interactions by including video-based feedback of an interaction partner's emotional state. This "emotional" Taylor Aggression Paradigm will 2) allow us to assess the neural correlates of BPD patients- aggressive reactions in social interactions. In addition, we will 3) test the modulation of two of the proposed biobehavioral mechanisms, namely threat hypersensitivity and approach rather than avoidance of social threat cues, using a pharmacological intervention with intranasally administered oxytocin. The results of this project will provide deeper insights into biobehavioral mechanisms mediating aggression in BPD. Moreover, the findings will enable the compilation of a test battery of behavioral markers, which can easily be used in the future for the clinical assessment of individual differences on the mechanistic level in the highly heterogeneous group of BPD patients. Together with IP2, they will pave the way for an empirically founded and individualized mechanism-based, time-restricted, and cost-effective intervention for aggression in the future.

攻击性是边缘型人格障碍的一个重要特征。尽管高患病率和个人以及社会成本所造成的侵略，神经生物学和行为（以下称为生物行为）的机制BPD的侵略仍然不清楚，经验成立的，有针对性的，具有成本效益的干预措施，减少侵略BPD仍然缺乏。基于第一个资助期的结果和以前的研究，我们最近提出了五个生物行为机制介导的BPD攻击，包括：威胁超敏反应，适应不良的愤怒调节，接近而不是回避社会威胁线索，认知同理心的赤字，和增强的情绪传染。本项目的目的是：1）调查有效性，即，这五种先前确定的生物行为机制对BPD攻击性的预测能力。攻击性将被实验性地激发，并使用一种新的MRI兼容的修改完善的泰勒攻击性范式来测量，该范式通过包括基于视频的互动伙伴情绪状态反馈来模仿现实生活中的社会互动。这种“情绪化”的泰勒攻击范式将使我们能够评估BPD患者的神经相关性--社会交往中的攻击性反应。此外，我们将3）使用鼻内给药催产素的药理学干预来测试两种拟议的生物行为机制的调节，即威胁超敏性和接近而不是回避社会威胁线索。该项目的结果将提供更深入的了解BPD中介导攻击的生物行为机制。此外，研究结果将使编译的测试电池的行为标志物，这可以很容易地用于在未来的临床评估的个体差异的机制水平上的高度异质性组的BPD患者。与IP 2一起，它们将为未来基于经验和个性化机制的、有时间限制的和具有成本效益的侵略干预铺平道路。

项目成果

Amygdala structure and aggressiveness in borderline personality disorder

• DOI: 10.1007/s00406-016-0747-9
• 发表时间: 2018-06-01
• 期刊: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
• 影响因子: 4.7
• 作者: Mancke，Falk;Herpertz，Sabine C.;Bertsch，Katja
• 通讯作者: Bertsch，Katja

EEG-vigilance regulation in Borderline Personality Disorder.

边缘性人格障碍的脑电图警戒调节

• DOI: 10.1016/j.ijpsycho.2019.02.007
• 发表时间: 2019
• 期刊: International journal of psychophysiology : official journal of the International Organization of Psychophysiology
• 作者: Kramer;Sander;Bertsch;Gescher;Cackowski;Hegerl;Herpertz
• 通讯作者: Herpertz

Heart rate variability in patients with post-traumatic stress disorder or borderline personality disorder: relationship to early life maltreatment

• DOI: 10.1007/s00702-016-1584-8
• 发表时间: 2016-09-01
• 期刊: JOURNAL OF NEURAL TRANSMISSION
• 影响因子: 3.3
• 作者: Meyer, Peter-Wolfgang;Mueller, Laura E.;Bertsch, Katja
• 通讯作者: Bertsch, Katja