Development of biodegradable iron-based alloys of the system Fe-Mn-C-(B, S) for the application as implant material

开发用作植入材料的 Fe-Mn-C-(B, S) 系可生物降解铁基合金

• 批准号: 277470500
• 负责人: Professorin Dr.-Ing. Julia Kristin Hufenbach
• 金额: --
• 依托单位: Institut für Werkstoffwissenschaft
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/277470500?language=en
• 关键词: Development; biodegradable; iron; based; alloys

Biodegradable metallic implant materials are increasingly gaining in significance for the aplication as temporary implants. This promotes the development of new as well as the further development of existing alloy systems and their comprehensive characterization. Due to the broad range of mechanical properties and the excellent processibility iron-based alloys are of great scientific and economic interest for stent application. In this project the influence of microalloying with boron or sulfur as well as the influence of higher cooling rates during solidification on the microstructure (e. g. phase formation, grain size), the mechanical properties (strength and formability), the degradation behavior (i. a. corrosion rate, corrosion mechanism) and the biological characteristics (e. g. cytotoxicity) on a Fe-30Mn-1C alloy shall be examined. Furthermore, generic stent demonstrators shall be build out of an alloy with great property potential by selective lasermelting (SLM) and subsequently be characterized. The aim is to develop novel iron-based alloys with an advantageous combination of mechanical, chemical and biological properties, which are quality-determining for the application as biodegradable stent. In addition, the processing of generic stent demonstrators with SLM as sustainable, technological and economical alternative shall be validated.

可生物降解金属种植体材料作为临时种植体的应用越来越受到重视。这促进了新合金系统的开发以及现有合金系统及其综合表征的进一步发展。铁基合金具有广泛的力学性能和良好的加工性能，在支架的应用中具有重要的科学价值和经济价值。在本项目中，研究了含硼或硫的微合金化以及凝固过程中较高的冷却速度对Fe-30Mn-1C合金的组织(如相的形成、晶粒度)、力学性能(强度和成形性)、退化行为(如腐蚀速度、腐蚀机理)和生物学特性(如细胞毒性)的影响。此外，通用支架演示器应由具有高性能潜力的合金通过选择性激光熔化(SLM)制造，并随后进行表征。其目的是开发具有机械、化学和生物性能的新型铁基合金，这些性能是作为生物可降解支架应用的质量决定因素。此外，应验证使用SLM作为可持续、技术和经济替代方案的普通支架演示器的加工。

项目成果

S and B microalloying of biodegradable Fe-30Mn-1C - Effects on microstructure, tensile properties, in vitro degradation and cytotoxicity

• DOI: 10.1016/j.matdes.2018.01.005
• 发表时间: 2018-03
• 期刊: Materials & Design
• 影响因子: 8.4
• 作者: J. Hufenbach;F. Kochta;H. Wendrock;A. Voß;L. Giebeler;S. Oswald;S. Pilz;U. Kühn;A. Lode

Effect of Selective Laser Melting on Microstructure, Mechanical, and Corrosion Properties of Biodegradable FeMnCS for Implant Applications

• DOI: 10.1002/adem.202000182
• 发表时间: 2020-04-29
• 期刊: ADVANCED ENGINEERING MATERIALS
• 影响因子: 3.6
• 作者: Hufenbach, Julia;Sander, Jan;Gebert, Annett
• 通讯作者: Gebert, Annett

Novel biodegradable Fe-Mn-C-S alloy with superior mechanical and corrosion properties

• DOI: 10.1016/j.matlet.2016.10.037
• 发表时间: 2017-01-01
• 期刊: MATERIALS LETTERS
• 影响因子: 3
• 作者: Hufenbach, J.;Wendrock, H.;Gebert, A.
• 通讯作者: Gebert, A.