Development of miniaturised fibre-reinforced composite structures for ultrasonic-based decontamination of non-shedding surfaces within the human organism

生物粘附现象和生物膜形成的非脱落表面在人类有机体是不同的病理的原因，往往是严重感染的触发器。在根管治疗中，化学机械去除根管系统中的细菌生物膜是一个重要的目标。为此，使用消毒剂与超声激活的冲洗针。初步的概念还没有提供一个完全令人满意的结果，因此，本提案的目的是为纤维增强聚合物（FRP）制成的小型化结构的新概念、建模和技术实现开发标准化、方法化和实验性原则。在医疗应用中，对小的和弯曲的中空空间（例如根管系统）进行优化的超声辅助清洁而不损伤表面是一个重要的目标。基本但部分相反的要求是降低超声针的断裂风险和保证高清洁效率。在初步工作中，复合材料在此类应用中的巨大潜力得到了证明。在本项目的范围内，将建立一个创新的标准化根管模型，考虑组织学和解剖学参数，以测试不同的FRP-针的工作安全性和清洁效果。调查是将FBR-超声系统转化为不同医学领域的基础。计划的任务涉及人类根管的抽象，参数化和分类，以量化自然和多样化的根管几何形状为目标。因此，我们将确立复合材料小型化结构的材料和制造概念，以降低断裂风险，同时确保高清洁效率。为了评估这些概念，在超声频率范围内激发的小型化结构的振动和故障行为将被建模和实验验证。在根管几何参数化的基础上，建立标准化的牙本质生物膜根管模型。这将允许清洁效果和牙本质损伤的可重复实验量化。因此，可以选择允许温和和有效清洁的材料概念。

Bioadhesion phenomena and biofilm formation on non-shedding surfaces in the human organism are the cause for different pathologies and often the trigger for severe infections. In endodontics (root canal treatment), it is an essential goal to remove the bacterial biofilm in the root canal system chemo-mechanically. For this purpose, disinfecting agents in combination with ultrasonically activated irrigation needles are used. Preliminary concepts have not provided a completely satisfactory outcome, yet.Therefore, the purpose of this proposal is the development of standardized, methodical and experimental principles for a new concept, modeling and technological realization of miniaturized structures made of fiber-reinforced polymers (FRP). An optimized ultrasonically-aided cleansing of small and curved hollow spaces (e.g. root canal systems) without the damage to surfaces in medical application is an important objective. Essential, but partially contrary requirements are the reduction of fracture risk of ultrasonic needles and the warranty of a high cleansing efficiency. In preliminary works, the great potential of composite materials for such applications was proven. Within the scope of this project, an innovative standardized root canal model, considering histological and anatomical parameters, will be established, in order to test different FRP-needles regarding work safety and cleansing efficacy.The investigations are the fundament for the translation of FBR-ultrasonic systems into different areas of medicine. The planned tasks involve the abstraction, parametrization and classification of human root canals with the quantification of natural and diverse canal geometries as its aim. Therefore, material- and manufacturing concepts for miniaturized structures made of composite materials will be established.These concepts are supposed to reduce the risk of fracture and to ensure a high cleansing efficiency, simultaneously. In order to evaluate these concepts, the vibrational and failure behavior of miniaturized structures excited within the ultrasonic frequency range will be modeled and validated experimentally. On the basis of the parameterized canal geometries, a standardized root canal model made of dentin with adherent biofilm will be established. This shall allow repeatable experimental quantification of cleansing effects and dentinal damage. Consequently, material concepts that allow a gentle and effective cleansing can be selected.