权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of miniaturised fibre-reinforced composite structures for ultrasonic-based decontamination of non-shedding surfaces within the human organism

开发微型纤维增强复合材料结构，用于人体有机体内不脱落表面的超声波净化

基本信息

批准号：
277550171
负责人：
Professor Dr.-Ing. Martin Dannemann
金额：
--
依托单位：
Institut für Leichtbau und Kunststofftechnik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2015
资助国家：
德国
起止时间：
2014-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/277550171?language=en
关键词：
Development miniaturised fibre reinforced composite

项目摘要

Bioadhesion phenomena and biofilm formation on non-shedding surfaces in the human organism are the cause for different pathologies and often the trigger for severe infections. In endodontics (root canal treatment), it is an essential goal to remove the bacterial biofilm in the root canal system chemo-mechanically. For this purpose, disinfecting agents in combination with ultrasonically activated irrigation needles are used. Preliminary concepts have not provided a completely satisfactory outcome, yet.Therefore, the purpose of this proposal is the development of standardized, methodical and experimental principles for a new concept, modeling and technological realization of miniaturized structures made of fiber-reinforced polymers (FRP). An optimized ultrasonically-aided cleansing of small and curved hollow spaces (e.g. root canal systems) without the damage to surfaces in medical application is an important objective. Essential, but partially contrary requirements are the reduction of fracture risk of ultrasonic needles and the warranty of a high cleansing efficiency. In preliminary works, the great potential of composite materials for such applications was proven. Within the scope of this project, an innovative standardized root canal model, considering histological and anatomical parameters, will be established, in order to test different FRP-needles regarding work safety and cleansing efficacy.The investigations are the fundament for the translation of FBR-ultrasonic systems into different areas of medicine. The planned tasks involve the abstraction, parametrization and classification of human root canals with the quantification of natural and diverse canal geometries as its aim. Therefore, material- and manufacturing concepts for miniaturized structures made of composite materials will be established.These concepts are supposed to reduce the risk of fracture and to ensure a high cleansing efficiency, simultaneously. In order to evaluate these concepts, the vibrational and failure behavior of miniaturized structures excited within the ultrasonic frequency range will be modeled and validated experimentally. On the basis of the parameterized canal geometries, a standardized root canal model made of dentin with adherent biofilm will be established. This shall allow repeatable experimental quantification of cleansing effects and dentinal damage. Consequently, material concepts that allow a gentle and effective cleansing can be selected.

人体非脱落表面的生物粘附现象和生物膜形成是不同病理的原因，往往是严重感染的触发因素。在牙髓学（根管治疗）中，化学机械去除根管系统中的细菌生物膜是一个重要的目标。为此目的，使用消毒剂与超声激活的冲洗针结合使用。初步的概念还没有提供一个完全令人满意的结果。因此，本提案的目的是为纤维增强聚合物（FRP）制成的小型化结构的新概念、建模和技术实现发展标准化、有条不紊和实验原理。优化超声辅助清洁小而弯曲的中空空间（如根管系统）而不损害表面在医疗应用中是一个重要的目标。基本的，但部分相反的要求是减少超声波针的断裂风险和保证高清洁效率。在初步工作中，证明了复合材料在此类应用中的巨大潜力。在本项目范围内，将建立一个创新的标准化根管模型，考虑组织学和解剖学参数，以测试不同的frp针的工作安全性和清洁效果。这些研究是将fbr -超声系统应用于不同医学领域的基础。计划的任务包括人类根管的抽象、参数化和分类，以量化自然和不同的根管几何形状为目标。因此，将建立由复合材料制成的微型化结构的材料和制造概念。这些概念旨在降低断裂风险，同时确保高清洁效率。为了评估这些概念，将对在超声频率范围内受激励的微型结构的振动和破坏行为进行建模和实验验证。在参数化根管几何形状的基础上，建立具有黏附生物膜的牙本质根管标准化模型。这将允许对清洁效果和牙本质损伤进行可重复的实验量化。因此，可以选择温和而有效的清洁材料概念。