Immunoregulatory Function of Human TCRαβ+ CD4-/CD8- Double Negative T cells and its Potential Role in Limiting Auto- and Alloreactive Immune Responses (B04)

调节性T细胞主要参与调节免疫反应，促进炎症消退。最近，一种新的TCR？？CD4-CD8-双阴性(DN)T细胞亚群被描述出来，它能抑制小鼠和人类的免疫反应。我们的目标是确定人类糖尿病肾病T细胞介导的炎症抑制的确切机制。此外，我们还将分析人糖尿病肾病T细胞在体内是否具有调节功能。了解人类糖尿病肾病T细胞抑制的机制可能对促进急性和/或慢性炎症的消退具有重要意义。

Regulatory T cells are mainly involved in modulating immune responses to promote resolution of inflammation. Recently, a novel subset of TCR¿¿+ CD4- CD8- double-negative (DN) T cells has been described, which suppresses immune responses in both mice and humans. We aim to identify the exact mechanisms of human DN T-cell mediated suppression of inflammation. Furthermore, we will analyze whether human DN T cells offer regulatory function in vivo. Understanding of the mechanisms involved in human DN T-cell suppression may have important implications for promoting the resolution of acute and/or chronic inflammation.