Immunoregulatory Function of Human TCRαβ+ CD4-/CD8- Double Negative T cells and its Potential Role in Limiting Auto- and Alloreactive Immune Responses (B04)

人 TCRαβ CD4-/CD8- 双阴性 T 细胞的免疫调节功能及其在限制自身和同种异体免疫反应中的潜在作用 (B04)

• 批准号: 277742046
• 金额: --
• 依托单位: Medizinische Klinik 5 -Hämatologie und Internistische Onkologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/277742046?language=en
• 关键词: Immunoregulatory; Function; Human; TCR; CD4

Regulatory T cells are mainly involved in modulating immune responses to promote resolution of inflammation. Recently, a novel subset of TCR¿¿+ CD4- CD8- double-negative (DN) T cells has been described, which suppresses immune responses in both mice and humans. We aim to identify the exact mechanisms of human DN T-cell mediated suppression of inflammation. Furthermore, we will analyze whether human DN T cells offer regulatory function in vivo. Understanding of the mechanisms involved in human DN T-cell suppression may have important implications for promoting the resolution of acute and/or chronic inflammation.

调节性T细胞主要参与调节免疫应答以促进炎症的消退。最近，一种新的TCR + CD 4-CD 8-双阴性（DN）T细胞亚群被描述，它抑制了小鼠和人类的免疫反应。我们的目的是确定人DN T细胞介导的炎症抑制的确切机制。此外，我们将分析人类DN T细胞是否提供体内调节功能。了解人类DN T细胞抑制的机制可能对促进急性和/或慢性炎症的消退具有重要意义。