Synthesis and characterization of a new thermosensitive MOF@Lipid nanocarrier system for MRI assisted targeted tumor therapy

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The aim of the research project is the synthesis and characterization of a new nanocarrier system that, assisted by magnetic resonance imaging (MRI) is suitable as a theranostic delivery system for targeted tumor therapy in humans. For that purpose a new, highly versatile and porous material class: metal-organic frameworks (MOFs) will be investigated. The key idea is to synergistically combine the features of MOF nanoparticles and thermosensitive liposomes (TSL) by creating functionalized MOF@Lipid systems. TSL are also nanocarriers, which are currently being tested clinically and which are under constant development. The major advantage of such a combined MOF@TSL system over TSL alone is the option to encapsulate a wider range of biologically active agents such as cytostatic and/or contrast agents. Additionally, the highly porous core of the MOF offers a higher loading capacity for therapeutical or diagnostic agents when compared to liposomes of the same size. The therapeutic concept is based on the creation of thermosensitive MOF nanocarriers that allow non-covalent loading of drugs and MRI contrast agents and additionally the controlled release of the agents in the target volume by local thermotherapy. The accumulation in the tumor and release of the contrast agent can be verified by MR imaging. Thus, MRI may allow to control the thermotherapy, to provide an indirect proof of drug release or even may allow quantification of drug release (chemodosimetry). Another benefit of an optimized non-covalent drug carrier MOF@TSL system is its feature to serve as a platform for other therapeutical applications.