Analysis and modulation of hippocampal functional connectivity between engram cells underlying spatial memory (B07)

空间记忆下印迹细胞之间海马功能连接的分析和调节（B07）

• 批准号: 280151203
• 金额: --
• 依托单位: Institut für Synaptische Physiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/280151203?language=en
• 关键词: Analysis; modulation; hippocampal; functional; connectivity

We use optogenetic and electrophysiological approaches to investigate how specific neuronal populations encode spatial memories. By activity-dependent expression of optogenetic silencers, we are able to shut off mossy cells that were highly active during encoding of a specific spatial location and test the effects on water maze performance. As we could show, learning of a new location typically re-activates dentate gyrus neurons encoding for the old location. We will investigate the importance of this reactivation for successful reversal learning and monitor learning-induced connectivity changes between the left and right hemisphere.

我们使用光遗传学和电生理学方法来研究特定神经元群如何编码空间记忆。通过光遗传沉默子的活性依赖表达，我们能够关闭在特定空间位置编码过程中高度活跃的苔藓细胞，并测试对水迷宫性能的影响。正如我们所展示的，学习一个新的位置通常会重新激活编码旧位置的齿状回神经元。我们将研究这种再激活对成功的反向学习的重要性，并监测学习诱导的左右脑半球连接变化。