Nanotubes from polymer conjugated cyclic peptides as a drug carrier for cancer therapy

我建议在沃里克大学的Sébastien Perrier教授小组中进行博士后研究，目的是合成功能性嵌段共聚物及其与环肽的结合。这些共轭物能够通过氢键自组装成纳米管。可接近的核-壳-冠结构将被交联并装载荧光探针和抗癌药物以制造标记的药物递送载体，所述药物递送载体将被分析其性质并在体外和体内进行研究。

The post-doctoral research, which I propose to perform at the University of Warwick within the group of Prof. Sébastien Perrier aims on the synthesis of functional block copolymers and their association to cyclic peptides. These conjugates are able to be self-assembled into nanotubes by the use of hydrogen bonds. The accessible core-shell-corona structures will be cross-linked and loaded with fluorescent probes and anti-cancer drugs to manufacture labeled drug delivery vehicles that will be analysed regarding their properties and studied in vitro and in vivo.