Deciphering genome function in animal development

破译动物发育中的基因组功能

• 批准号: FF0776096
• 负责人: Prof Peter Koopman
• 金额: $ 113.93万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Federation Fellowships
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-11-01 至 2012-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FF0776096
• 关键词: Deciphering; genome; function; animal; development

The normal development of an embryo depends on complex and finely tuned gene regulatory mechanisms. In this Fellowship, I will use sophisticated new technologies to discover which of our 30,000 genes is important for embryonic development, reveal the roles of these genes, and identify the control mechanisms that can go awry to cause birth defects. Our research will suggest new ways to diagnose and deal with these conditions, and will be applicable to stem cell technologies, tissue regeneration, cancer biology, conservation, pest management and livestock breeding, thus delivering significant economic and social benefits to Australia.

胚胎的正常发育取决于复杂而精细的基因调控机制。在这个奖学金中，我将使用先进的新技术来发现我们的30，000个基因中哪些对胚胎发育很重要，揭示这些基因的作用，并确定可能导致出生缺陷的控制机制。我们的研究将提出诊断和处理这些疾病的新方法，并将适用于干细胞技术、组织再生、癌症生物学、保护、害虫管理和牲畜养殖，从而为澳大利亚带来重大的经济和社会效益。