How the Y Chromosome makes a male: Molecular genetic analysis of key sex-determining genes

性逆转和中间性综合征是影响新生儿的最常见和最受歧视的疾病之一。我们的研究将揭示Y染色体如何调节正常的男性发育，确定许多男性婴儿出现问题的步骤，并提出诊断和处理这些疾病的方法。它还将为干细胞技术、害虫管理、野生动物保护和动物繁殖等领域的生物技术应用铺平道路。

Sex reversal and intersex syndromes are among the most common and highly stigmatized disorders affecting newborn babies. Our research will reveal how the Y chromosome regulates normal male development, identify the steps that go wrong in many male babies, and suggest ways to diagnose and deal with these conditions. It will also pave the way for biotechnological applications in the areas of stem cell technology, pest management, wildlife conservation and animal breeding.