How the Y Chromosome makes a male: Molecular genetic analysis of key sex-determining genes

Y 染色体如何形成男性：关键性别决定基因的分子遗传学分析

• 批准号: DP0770036
• 负责人: Prof Peter Koopman
• 金额: $ 91.93万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770036
• 关键词: How; Chromosome; makes; male; Molecular

Sex reversal and intersex syndromes are among the most common and highly stigmatized disorders affecting newborn babies. Our research will reveal how the Y chromosome regulates normal male development, identify the steps that go wrong in many male babies, and suggest ways to diagnose and deal with these conditions. It will also pave the way for biotechnological applications in the areas of stem cell technology, pest management, wildlife conservation and animal breeding.

性别逆转和双性人综合症是影响新生儿的最常见和高度污名化的疾病。我们的研究将揭示Y染色体如何调节正常的男性发育，确定许多男性婴儿出现问题的步骤，并提出诊断和处理这些疾病的方法。它还将为生物技术在干细胞技术、病虫害管理、野生动物保护和动物育种等领域的应用铺平道路。