Chiral-at-Metal Lewis Acid Catalysts

只含有非手性配体的八面体手性金属配合物是一类在不对称催化中应用的未被充分研究的金属配合物。然而，金属中心的手性与金属配位的底物非常接近，这保证了在不对称诱导过程中手性的高效转移。因此，本项目的目标是开发八面体手性金属络合物，特别是双环金属Ir(III)和Rd(III)络合物，作为手性Lewis酸在不对称催化中的应用。双环金属Ir(III)络合物的光物理性质为开发可见光活化的不对称催化剂提供了另一个吸引人的特征。在这个项目的过程中，我们期待着新型不对称催化剂和潜在的新型反应类型的发展。

Octahedral chiral-at-metal complexes bearing solely achiral ligands constitute an underinvestigated class of metal complexes for applications in asymmetric catalysis. However, the close proximity of the metal-centered chirality to the metal-coordinated substrate promises a highly effective transfer of chirality in the course of the asymmetric induction. Goal of this project is therefore the development of octahedral chiral-at-metal complexes, particularly bis-cyclometalated iridium(III) and rhodium(III) complexes, as chiral Lewis acids for applications in asymmetric catalysis. The established photophysical properties of bis-cyclometalated iridium(III) complexes provide an additional attractive feature for the development of visible-light-activated asymmetric catalysts. We anticipate the development of novel asymmetric catalysts and potentially novel reaction types in the course of this project.