Chiral-at-Metal Lewis Acid Catalysts

八面体手性金属配合物是一类研究较少的金属配合物，在不对称催化反应中有着广泛的应用。然而，金属为中心的手性的金属配位基板的紧密接近，承诺在不对称诱导的过程中的手性的高效转移。因此，本项目的目标是开发八面体手性金属配合物，特别是双环化铱（III）和铑（III）配合物，作为手性刘易斯酸在不对称催化中的应用。二环化铱（III）配合物的物理化学性质为可见光活化的不对称催化剂的开发提供了一个额外的吸引人的功能。我们期待在这个项目的过程中开发新的不对称催化剂和潜在的新反应类型。

Octahedral chiral-at-metal complexes bearing solely achiral ligands constitute an underinvestigated class of metal complexes for applications in asymmetric catalysis. However, the close proximity of the metal-centered chirality to the metal-coordinated substrate promises a highly effective transfer of chirality in the course of the asymmetric induction. Goal of this project is therefore the development of octahedral chiral-at-metal complexes, particularly bis-cyclometalated iridium(III) and rhodium(III) complexes, as chiral Lewis acids for applications in asymmetric catalysis. The established photophysical properties of bis-cyclometalated iridium(III) complexes provide an additional attractive feature for the development of visible-light-activated asymmetric catalysts. We anticipate the development of novel asymmetric catalysts and potentially novel reaction types in the course of this project.