Chiral-at-Metal Lewis Acid Catalysts

仅含非手性配体的八面体手性金属配合物是一类应用于不对称催化的金属配合物。然而，在不对称诱导过程中，金属中心手性与金属配位底物的接近性保证了手性的高效转移。因此，本项目的目标是开发八面体手性金属配合物，特别是双环金属化铱（III）和铑（III）配合物，作为手性路易斯酸在不对称催化中的应用。已建立的双环金属化铱（III）配合物的光物理性质为开发可见光活化的不对称催化剂提供了另一个有吸引力的特征。我们期望在这个项目的过程中开发新的不对称催化剂和潜在的新反应类型。

Octahedral chiral-at-metal complexes bearing solely achiral ligands constitute an underinvestigated class of metal complexes for applications in asymmetric catalysis. However, the close proximity of the metal-centered chirality to the metal-coordinated substrate promises a highly effective transfer of chirality in the course of the asymmetric induction. Goal of this project is therefore the development of octahedral chiral-at-metal complexes, particularly bis-cyclometalated iridium(III) and rhodium(III) complexes, as chiral Lewis acids for applications in asymmetric catalysis. The established photophysical properties of bis-cyclometalated iridium(III) complexes provide an additional attractive feature for the development of visible-light-activated asymmetric catalysts. We anticipate the development of novel asymmetric catalysts and potentially novel reaction types in the course of this project.