Ruthenium Complexes with Exclusive Octahedral Centrochirality for Asymmetric Catalysis

手性是不对称催化剂的一个重要特征。我们小组在手性金属路易斯酸催化剂的应用方面做出了重要贡献，其中八面体金属中心构成了唯一的手性来源。这类催化剂由于其固有的结构简单(仅限于非手性配体)以及由于手性金属中心与金属配位的底物或试剂之间的密切接触而具有特别有效的不对称诱导的前景而引起人们的兴趣。由于我们以前的工作完全集中在双环金属化的Ir和Rh的络合物上，因此我们的目标是将这类手性金属Lewis酸催化剂扩展到其他金属。具体地说，我们建议研究和开发具有独有的八面体中心手性的Ru基手性Lewis酸催化剂。在这个项目的过程中，我们期待着用于潜在的新型反应类型的新型不对称催化剂的开发。

Chirality is a pivotal feature of asymmetric catalysts. Our group has made important contributions to the use of chiral-at-metal Lewis acid catalysts in which the octahedral metal center constitutes the exclusive source of chirality. Such catalysts are of interest due to their intrinsic structural simplicity (only achiral ligands) and the prospect of an especially effective asymmetric induction due to the intimate contact between the chiral metal center and the metal-coordinated substrate or reagent. Since our previous work was entirely focused on bis-cyclometalated iridium and rhodium complexes, it is our objective to expand this class of chiral-at-metal Lewis acid catalysts to other metals. Specifically, we propose to investigate and develop ruthenium-based chiral Lewis acid catalysts with exclusive octahedral centrochirality. We anticipate the development of novel asymmetric catalysts for potentially novel reaction types in the course of this project.