Ruthenium Complexes with Exclusive Octahedral Centrochirality for Asymmetric Catalysis

手性是不对称催化剂的关键特征。我们的团队在八面体金属中心构成手性唯一来源的手性金属路易斯酸催化剂的使用方面做出了重要贡献。这种催化剂由于其固有的结构简单（只有非手性配体）和由于手性金属中心与金属配位的底物或试剂之间的密切接触而具有特别有效的不对称诱导的前景而引起人们的兴趣。由于我们之前的工作完全集中在双环金属化铱和铑配合物上，我们的目标是将这类手性金属路易斯酸催化剂扩展到其他金属上。具体而言，我们建议研究和开发具有独占八面体中心手性的钌基手性路易斯酸催化剂。我们期望在这个项目的过程中开发出新的不对称催化剂，用于潜在的新反应类型。

Chirality is a pivotal feature of asymmetric catalysts. Our group has made important contributions to the use of chiral-at-metal Lewis acid catalysts in which the octahedral metal center constitutes the exclusive source of chirality. Such catalysts are of interest due to their intrinsic structural simplicity (only achiral ligands) and the prospect of an especially effective asymmetric induction due to the intimate contact between the chiral metal center and the metal-coordinated substrate or reagent. Since our previous work was entirely focused on bis-cyclometalated iridium and rhodium complexes, it is our objective to expand this class of chiral-at-metal Lewis acid catalysts to other metals. Specifically, we propose to investigate and develop ruthenium-based chiral Lewis acid catalysts with exclusive octahedral centrochirality. We anticipate the development of novel asymmetric catalysts for potentially novel reaction types in the course of this project.