Reversible Single-Chain Folding of Macromolecules via Non-Covalent Interactions (A01)

通过非共价相互作用实现大分子的可逆单链折叠 (A01)

• 批准号: 283643253
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/283643253?language=en
• 关键词: Reversible; Single; Chain; Folding; Macromolecules

In contrast to the at least partially understood folding of polypeptides to proteins, the understanding of the mechanistic principles of the folding of polymers into single chain nanoparticles (SCNPs) is still in its infancy. Complex macromolecules with several novel covalent and non-covalent (photochemically controlled) folding points will be explored and their compaction studied in detail on an atomistic level using a variety of sophisticated NMR-spectroscopic methods.

与至少部分了解的多肽折叠成蛋白质相比，对聚合物折叠成单链纳米粒子（SCNP）的机械原理的理解仍处于起步阶段。将探索具有多个新颖共价和非共价（光化学控制）折叠点的复杂大分子，并使用各种复杂的核磁共振波谱方法在原子水平上详细研究它们的压实。