Role of aberrant neural oscillations for multisensory processing deficits in schizophrenia

异常神经振荡对精神分裂症多感觉处理缺陷的作用

• 批准号: 289167885
• 负责人: Professor Dr. Daniel Senkowski
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie (CCM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/289167885?language=en
• 关键词: Role; aberrant; neural; oscillations; multisensory

Periodic fluctuations of excitatory and inhibitory states, as reflected in neural oscillations, are crucial for information processing in cortical networks. Dysfunctional neural connectivity, which has been linked to abnormal oscillations, presumably contributes to the pathophysiology in schizophrenia (ScZ). Studies examining neural oscillations in ScZ have primarily used unisensory stimulation protocols. Recent behavioral and neuroimaging studies have also suggested multisensory processing deficits in ScZ, but the neurophysiologic mechanisms underlying these deficits are not well understood. The integration of multisensory stimuli requires information processing across multiple senses and neural oscillations play an important role therein. For these reasons, multisensory paradigms are promising for studying neural oscillations in ScZ patients. The central goal of this proposal is to test the assumption that abnormal neural oscillations contribute to multisensory processing deficits in ScZ. The project comprises of four electroencephalography studies using multisensory paradigms for which effects in neural oscillations have been previously established in healthy participants. To reveal a more global picture of multisensory processing in ScZ, the experiments feature a wide range of research questions. Experiment 1 will address how motion congruence affects the processing of visuotactile stimuli, as reflected in gamma-band oscillations (GBO > 30 Hz) in sensory cortices. Experiment 2 will examine audiovisual speech processing under noisy acoustic conditions, as expressed in beta-band oscillations (13-30 Hz) in the superior temporal sulcus. Experiment 3 will investigate the processing of crossmodal prediction errors generated by audiovisual speech, as observed in theta-band oscillations (4-7 Hz) and GBO. Experiment 4 will focus on the influence of top-down attention on early evoked GBO to basic audiovisual stimuli. State-of-the-art analysis approaches will be applied to examine multisensory processing, as reflected in local power, dynamic network patterns, and functional connectivity in ScZ patients and healthy control participants. The experiments will uncover whether abnormalities in these measures relate to the ScZ pathophysiology. Taken together, the project will substantially advance our understanding of how aberrant neural oscillations contribute to multisensory processing deficits in schizophrenia.

兴奋和抑制状态的周期性波动，反映在神经振荡中，对皮层网络中的信息处理至关重要。功能障碍的神经连接，这已被链接到异常振荡，大概有助于精神分裂症（ScZ）的病理生理。检查ScZ中的神经振荡的研究主要使用unisensory刺激协议。最近的行为和神经影像学研究也表明，多感觉加工缺陷的ScZ，但这些缺陷的神经生理机制还没有得到很好的理解。多感觉刺激的整合需要跨多个感觉的信息处理，神经振荡在其中起着重要作用。由于这些原因，多感觉范例是有前途的研究神经振荡的ScZ患者。这项建议的中心目标是测试的假设，异常的神经振荡有助于多感觉处理缺陷的ScZ。该项目包括四项使用多感觉范式的脑电图研究，其神经振荡的影响先前已在健康参与者中建立。为了揭示ScZ中多感觉处理的更全面的画面，实验的特点是广泛的研究问题。实验1将讨论运动一致性如何影响视触刺激的处理，如感觉皮层中的伽马波段振荡（GBO > 30 Hz）所反映的。实验2将检查在嘈杂的声学条件下的视听语音处理，如在上级颞沟中的β带振荡（13-30 Hz）所表示的。实验3将研究视听语音产生的跨模态预测误差的处理，如在θ波段振荡（4-7 Hz）和GBO中观察到的。实验四主要考察自上而下注意对基本视听刺激诱发的早期GBO的影响。国家的最先进的分析方法将被应用于检查多感官处理，反映在本地电源，动态网络模式，并在ScZ患者和健康对照参与者的功能连接。这些实验将揭示这些指标的异常是否与ScZ病理生理学有关。总之，该项目将大大推进我们对异常神经振荡如何导致精神分裂症多感觉处理缺陷的理解。