Functional regulation of the mitochondrial presequence translocation complex (P12)

线粒体前序列易位复合体的功能调节 (P12)

• 批准号: 290057880
• 金额: --
• 依托单位: Biochemie-Zentrum (BZH)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/290057880?language=en
• 关键词: Functional; regulation; mitochondrial; presequence; translocation

Over half of the proteins of a eukaryotic cell have to cross at least one membrane to reach their designated localization. In virtually all cellular membranes protein translocation machineries have been identified that either transport proteins across a membrane or facilitate their insertion into a particular membrane. At the heart of many of these translocation machineries protein conducting pores have been found that mediate import, export and membrane insertion. This project focuses on the molecular characterization of two protein conducting pores within the TIM23 and the Hrd1 complexes, that cover all three mentioned protein transport pathways.

真核细胞中超过一半的蛋白质必须穿过至少一个膜才能达到指定的定位。在几乎所有的细胞膜中，蛋白质转运机制都已被发现，它们要么通过细胞膜运输蛋白质，要么促进蛋白质插入特定的细胞膜。在许多这些转位机制的核心，蛋白质传导孔被发现参与介导输入、输出和膜插入。本项目重点研究TIM23和Hrd1复合体中两个蛋白质传导孔的分子特征，这两个孔覆盖了上述三条蛋白质运输途径。