RadioGenes2: Modelling complex biomolecular interactions in radiated tumours: Towards understanding the genesis of therapeutic radioresistance.

RadioGenes2：模拟辐射肿瘤中复杂的生物分子相互作用：了解治疗性放射抗性的起源。

• 批准号: DP0774601
• 负责人: Dr Jesus Lopez
• 金额: --
• 依托单位: University of Southern Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-01-11
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0774601
• 关键词: RadioGenes2; Modelling; complex; biomolecular; interactions

About 45% of bladder cancer patients require radiotherapy or surgery. Radiotherapy has a failure rate of ~50%. Surgery (bladder removal) diminishes quality of life considerably. Modelling complex gene interactions in radiated cancer cells will provide crucial knowledge on the molecular genesis of radiotherapy-resistance of tumours. Our findings will provide: (i) an accurate mathematical/computational model for diagnosing radiosensitivity; (ii) further insights to be applied in the pharmaceutical sector such as the discovery of novel molecular targets that have the potential to increase radiotherapy success ratios; (iii) a holistic modelling technique applicable to a larger diversity of tumours.

约45%的膀胱癌患者需要接受放射治疗或手术。放射治疗的失败率约为50%。手术(膀胱摘除)大大降低了生活质量。对辐射癌细胞中复杂的基因相互作用进行建模，将为肿瘤放射抗性的分子起源提供重要的知识。我们的发现将提供：(I)诊断放射敏感性的准确数学/计算模型；(Ii)将应用于制药部门的进一步见解，例如发现有可能提高放射治疗成功率的新分子靶点；(Iii)适用于更大多样性肿瘤的整体建模技术。