The association of PCSK7 with coronary calcification

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PCSK7と中性脂肪・肥満・脂肪肝との関連を共同研究者の古橋とともに報告した (Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication.Furuhashi M, Kataoka Y, Nishikawa R, Koyama M, Sakai A, Higashiura Y, Tanaka M, Saitoh S, Shimamoto K, Ohnishi H. J Atheroscler Thromb. 2022 Sep 1;29(9):1275-1284.)。ガイドラインにより推奨される薬物治療・血行再建術実施でも予後不良な冠動脈石灰化を報告した (Cardiac outcomes in patients with acute coronary syndrome attributable to calcified nodule. Sugane H, Kataoka Y, Otsuka F, Nakaoku Y, Nishimura K, Nakano H, Murai K, Honda S, Hosoda H, Matama H, Doi T, Nakashima T, Fujino M, Nakao K, Yoneda S, Tahara Y, Asaumi Y, Noguchi T, Kawai K, Yasuda S. Atherosclerosis. 2021 Feb;318:70-75.)。厳格なLDL-C管理下でも治療抵抗性な 冠動脈石灰化の特徴を報告した (Phenotypic Features of Coronary Atheroma in Diabetic and Nondiabetic Patients With Low-Density Lipoprotein Cholesterol <55 mg/dL. Iwai T, Kataoka Y, Nicholls SJ, Puri R, Murata S, Nishimura K, Murai K, Kitahara S, Sawada K, Matama H, Honda S, Takagi K, Fujino M, Yoneda S, Otsuka F, Nishihira K, Asaumi Y, Miyamoto Y, Yasuda S, Noguchi T. JACC Cardiovasc Imaging. 2022 Jun;15(6):1166-1169.)