Computer modeling of cardiac conduction system for arrhythmia research and implantable device testing

用于心律失常研究和植入式设备测试的心脏传导系统计算机建模

• 批准号: 20K12046
• 负责人: Maxim・V Ryzhii
• 金额: $ 1.58万
• 依托单位: The University of Aizu
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K12046/
• 关键词: atrioventricular node; rabbit heart model; Aliev-Panfilov model; dual pathway; cardiac conduction curve; coupling asymmetry; retrograde conduction; ladder diagram; Corrado-Niederer; Aliev-Panfilov; "natural pacemaker"; "nonlinear equation"; "d

The atrioventricular node (AVN) is considered a ”black box”, and the functioning of its dual pathways remains controversial and not fully understood. We have developed a compact, computationally lightweight multi-functional rabbit AVN model based on the Aliev-Panfilov two-variable cardiac cell model. The 1D AVN model includes fast and slow pathways, primary pacemaking in the sinoatrial node, and subsidiary pacemaking in the slow pathway.We implemented the asymmetry of coupling between model cells to obtain the direction-dependent conduction properties of the AVN, together with gradients of intercellular coupling and cell refractoriness. The AVN model demonstrates broad functionality, including normal sinus rhythm, AVN automaticity, filtering of high-rate atrial rhythms during atrial fibrillation and atrial flutter, direction-dependent properties, and realistic anterograde and retrograde conduction curves in the control case and the cases of fast and slow pathway ablation. In addition, the model is accompanied by a visualization of electrical conduction in the AVN, revealing the interaction between fast and slow pathways in the form of ladder diagrams. To show the validity of the proposed model, we compare the simulation results with the available experimental data.The proposed model can be used both as a stand-alone module and as a part of complex 3D atrial or whole heart simulation systems. The results were published in the journal "Frontiers in Physiology" (impact factor 4.755), and the MATLAB source code was placed in a public repository.

房室结（AVN）被认为是一个“黑匣子”，其双通路的功能仍然存在争议，尚未完全了解。我们已经开发了一个紧凑的，计算轻量级的多功能兔AVN模型的基础上Aliev-Panfilov两个变量的心脏细胞模型。一维房室结模型包括快径和慢径，窦房结的主起搏和慢径的辅助起搏，我们实现了模型细胞之间耦合的不对称性，以获得房室结的方向依赖性传导特性，以及细胞间耦合和细胞不应性的梯度。房室结模型显示了广泛的功能，包括正常窦性心律、房室结自律性、房颤和房扑期间高频率房性心律的过滤、方向依赖性以及对照病例和快速和慢速通路消融病例中的真实顺行和逆行传导曲线。此外，该模型还伴随着AVN中的电传导的可视化，以梯形图的形式揭示了快和慢通路之间的相互作用。为了验证该模型的有效性，我们将仿真结果与实验数据进行了比较，该模型既可以作为一个独立的模块，也可以作为复杂的三维心房或全心脏仿真系统的一部分。结果发表在《生理学前沿》杂志上（影响因子4.755），MATLAB源代码被放置在公共存储库中。

项目成果

MATLAB and CellML source codes for PLOS One, 2022

PLOS One 的 MATLAB 和 CellML 源代码，2022

Comparison of Responses of Ion-Channel and Simplified Pacemaker Cell Models on External Stimulation

离子通道和简化起搏细胞模型对外部刺激的反应比较

• DOI: 10.1109/bibm52615.2021.9669353
• 发表时间: 2021
• 期刊: Proceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021
• 作者: Nasution;Ahmad Kamal;Sony Hartono Wijaya;Pei Gao;Rumman Mahfujul Islam;Ming Huang;Naoaki Ono;Shigehiko Kanaya;and Md Altaf-Ul-Amin;松田 憲・杉森絵里子・楠見 孝;M. Ryzhii and E. Ryzhii
• 通讯作者: M. Ryzhii and E. Ryzhii

Simulation of ectopic activity onset in border zones between normal and damaged myocardium with minimal ionic models

用最小离子模型模拟正常心肌和受损心肌之间边界区域的异位活动开始

• DOI: 10.22489/cinc.2020.142
• 发表时间: 2020
• 期刊: 2020 Computing in Cardiology, CinC 2020
• 作者: Ryzhii Maxim;Ryzhii Elena
• 通讯作者: Ryzhii Elena

Video presentation at CinC 2020 Conference

CinC 2020 会议上的视频演示

Simulation of the Effect of AC stimulation on Atrioventricular Node with Nonlinear Model

非线性模型模拟交流电刺激对房室结的影响

• DOI: 10.1109/esgco49734.2020.9158159
• 发表时间: 2020
• 期刊: Proc. of 11th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)
• 作者: M. Ryzhii;E. Ryzhii
• 通讯作者: E. Ryzhii