Computer modeling of cardiac conduction system for arrhythmia research and implantable device testing

房室结(AVN)被认为是一个“黑匣子”，其双通路的功能仍存在争议，尚未完全了解。我们在Aliev-Panfilov双变量心肌细胞模型的基础上发展了一种紧凑、计算轻便的多功能兔房室结模型。一维房室结模型包括快径和慢径、窦房结的初级起搏和慢径的辅助起搏，通过细胞间耦合的不对称性获得房室结的方向相关传导特性，以及细胞间耦合和细胞不应性的梯度。房室结模型显示了广泛的功能，包括正常的窦性心律，房室结的自动性，在房颤和心房扑动期间过滤高频率的房性心律，方向相关的特性，以及在对照组和快径和慢径消融病例中真实的顺行和逆传传导曲线。此外，该模型还伴随着AVN中导电的可视化，以梯形图的形式揭示了快路径和慢路径之间的相互作用。为了验证该模型的有效性，我们将仿真结果与已有的实验数据进行了比较，该模型既可以作为一个独立的模块使用，也可以作为复杂的3D心房或整个心脏仿真系统的一部分。研究结果发表在期刊《生理学前沿》(影响因子4.755)上，并将matlab源代码放入公共储存库。

The atrioventricular node (AVN) is considered a ”black box”, and the functioning of its dual pathways remains controversial and not fully understood. We have developed a compact, computationally lightweight multi-functional rabbit AVN model based on the Aliev-Panfilov two-variable cardiac cell model. The 1D AVN model includes fast and slow pathways, primary pacemaking in the sinoatrial node, and subsidiary pacemaking in the slow pathway.We implemented the asymmetry of coupling between model cells to obtain the direction-dependent conduction properties of the AVN, together with gradients of intercellular coupling and cell refractoriness. The AVN model demonstrates broad functionality, including normal sinus rhythm, AVN automaticity, filtering of high-rate atrial rhythms during atrial fibrillation and atrial flutter, direction-dependent properties, and realistic anterograde and retrograde conduction curves in the control case and the cases of fast and slow pathway ablation. In addition, the model is accompanied by a visualization of electrical conduction in the AVN, revealing the interaction between fast and slow pathways in the form of ladder diagrams. To show the validity of the proposed model, we compare the simulation results with the available experimental data.The proposed model can be used both as a stand-alone module and as a part of complex 3D atrial or whole heart simulation systems. The results were published in the journal "Frontiers in Physiology" (impact factor 4.755), and the MATLAB source code was placed in a public repository.