Restriction of dietary vitamin reveals metabolic vulnerability of small cell lung cancer

膳食维生素的限制揭示了小细胞肺癌的代谢脆弱性

• 批准号: 20K17203
• 负责人: Morita Mami
• 金额: $ 2.66万
• 依托单位: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K17203/
• 关键词: 肺がん; 代謝; NAD; 小細胞肺がん; 食事介入

项目成果

Restriction of the dietary niacin enhances NAD-targeting therapy in mice

限制饮食烟酸可增强小鼠 NAD 靶向治疗

• 发表时间: 2022
• 作者: Miyuki Nomura;Tomoyoshi Soga;Shusuke Akamatsu;Mami Morita;Yoji Yamashita;Hiroshi Shima;Hidekazu Yamada;Taku Sato;Nobuhiro Tanuma
• 通讯作者: Nobuhiro Tanuma

Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy.

• DOI: 10.1016/j.bbrc.2020.07.082
• 发表时间: 2020-09
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: N. Kikuchi;T. Soga;Miyuki Nomura;Taku Sato;Yoshimi Sakamoto;R. Tanaka;Jiro Abe;Mami Morita;H. Shima;Y. Okada;N. Tanuma

Dietary intervention as a therapeutic for cancer.

• DOI: 10.1111/cas.14777
• 发表时间: 2021-03
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Morita M;Kudo K;Shima H;Tanuma N
• 通讯作者: Tanuma N

Osimertinib in poor performance status patients with T790M-positive advanced non-small-cell lung cancer after progression of first- and second-generation EGFR-TKI treatments (NEJ032B).

• DOI: 10.1007/s10147-021-02043-2
• 发表时间: 2022-01
• 期刊: International journal of clinical oncology
• 影响因子: 3.3
• 作者: Tsubata Y;Watanabe K;Saito R;Nakamura A;Yoshioka H;Morita M;Honda R;Kanaji N;Ohizumi S;Jingu D;Nakagawa T;Nakazawa K;Mouri A;Takeuchi S;Furuya N;Akazawa Y;Miura K;Ichihara E;Maemondo M;Morita S;Kobayashi K;Isobe T
• 通讯作者: Isobe T

NAD dependence of small-cell lung and prostate cancers

小细胞肺癌和前列腺癌的 NAD 依赖性

• 发表时间: 2022
• 作者: Nobuhiro Tanuma;Shuko Miya-hara;Miyuki Nomura;Tomoyoshi Soga;Shusuke Akamatsu;Mami Morita;Yoji Yamashita;Hiroshi Shima;Hidekazu Yamada;Taku Sato,
• 通讯作者: Taku Sato,