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血管内皮機能に着目した新しいサルコペニア予防に対する栄養教育戦略の創出

创建以血管内皮功能为重点的预防肌肉减少症的新营养教育策略

基本信息

批准号：
20K19730
负责人：
横路三有紀
金额：
$ 2.75万
依托单位：
Mukogawa Women's University Junior College Division
依托单位国家：
日本
项目类别：
Grant-in-Aid for Early-Career Scientists
财政年份：
2020
资助国家：
日本
起止时间：
2020-04-01 至 2024-03-31
项目状态：
已结题

项目摘要

昨年度、地域在住女性高齢者において血中ADMA濃度が高い人ほどサルコペニアの罹患率が高いことや2年後の骨格筋の減少が認められることを示すデータが得られた。しかし、血中ADMA濃度と食事摂取との関連は明らかになっていない。本年度はまず、血管内皮機能、血管機能をキーワードとして、それらを改善する食事や食品成分に関する系統的レビュー論文の探索を行った。結果、カリウム摂取量、食品に含まれる硝酸塩や亜硝酸塩が血管機能に良い影響を与えることが報告されていた。カリウムだけでなく、硝酸塩や亜硝酸塩は根菜や葉物野菜など野菜類に多く含まれることが明らかとなっている。我々は非肥満糖尿病（DM）患者において尿中Na/K比と血中ADMA濃度が正の関連を示すこと、一人暮らし高齢者は同居高齢者に比し、男女とも野菜類の摂取頻度が低下することを報告している。これらより、血管内皮機能に着目したサルコペニア予防のための栄養教育として、2023年度に一人暮らし高齢者を対象に野菜摂取を促す栄養教育を実施することを計画している。次に、インスリン注射をしていない2型糖尿病患者を対象として、これまで報告されている食事法（Healthy Eating Index 2015, HEI-2015; 地中海食; Dietary Approaches to Stop Hypertension, DASH)と血中ADMA濃度の関連を解析した。結果、非肥満DM群ではHEI-2015スコアと血中ADMA濃度に有意な負の関連が示されたが、肥満DM群では認められなかった。地中海食スコアやDASHスコアと血中ADMA濃度は非肥満DM群、肥満群DM群どちらにおいても関連は認められなかった。以上より、HEI-2015に則った食事法は血中ADMA濃度の低下に有用である可能性が示された。

Last year, the ADMA in the blood of women living in high school was high, the attack rate was high, and two years later, there were fewer bones and tendons, which showed that there were fewer bones and tendons. ADMA in blood, food, food and food. This year, the vascular endothelial mechanism and vascular mechanism are used to improve the quality of food, food components, food components, food, food and food. Results: the results showed that the amount of food, the content of nitric acid, the concentration of nitric acid, the vascular system, the balance of blood vessels, the quantity of food, the amount of nitric acid, the amount of nitric acid, the amount of food, the amount of nitric acid, the amount of nitric acid, the amount of food, the amount of food, the amount of nitric acid, the amount of nitric acid, the amount of food, the amount of nitric acid, the amount of food, the amount of food, the amount of nitric acid, the amount of food, the amount of Many kinds of vegetables, such as wild vegetables, wild vegetables and wild vegetables. The urine Na/K level of patients with non-obese diabetes mellitus (DM) was higher than that of ADMA in blood. The level of urine ADMA was higher than that of patients with non-obese diabetes mellitus (NIDDM). The results showed that the level of urinary DNA in patients with non-obese diabetes was higher than that in patients with non-obese diabetes (NIDDM). In the year 2023, a person who is in the twilight of the year is like a wild vegetable to promote the education of health education. In patients with type 2 diabetes, patients with type 2 diabetes were treated with dietary methods (Healthy Eating Index 2015, HEI-2015; Mediterranean food; Dietary Approaches to Stop Hypertension, DASH). Blood ADMA levels were analyzed. Results: the blood ADMA concentration of non-obese DM population was significantly higher than that of non-obese DM population. In the Mediterranean diet, the blood ADMA concentration is not high, but the blood ADMA concentration is not fat. The DM group, the fat group, the DM group, the diet group, the body weight group, the weight group, the body weight group, the fat group, the DM group, the diet group, the DM group, the non-fat group and the fat group. The above drugs, HEI-2015 drugs, low levels of ADMA in the blood of the Dietetic Law, are useful, and the possibility indicates that they are not.

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Relationship Between Dietary Variety and Frailty in Older Japanese Women During the Period of Restriction on Outings Due to COVID-19

DOI：
10.1093/geronb/gbaa218
发表时间：
2021-09-01
期刊：
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
影响因子：
6.2
作者：
Otaki, Naoto;Yano, Megumu;Fukuo, Keisuke
通讯作者：
Fukuo, Keisuke

The association between life satisfaction and self-rated health among Japanese elderly who live alone

日本独居老人生活满意度与自评健康的关系

DOI：
发表时间：
2022
期刊：
日本予防医学会雑誌
影响因子：
0
作者：
Nishimura Y;Otaki N;Yokoro M;Yano M;Akita M;Hayashi K;Tanino N;Fukuo K
通讯作者：
Fukuo K

Yokoro M, Otaki N, Yano M, Imamura T, Maeda K, Tanino N, Fukuo K

Yokoro M、Otaki N、Yano M、Imamura T、Maeda K、Tanino N、Fukuo K

DOI：
发表时间：
2021
期刊：
Asia Pac J Clin Nutr
影响因子：
1.3
作者：
Tomu MAKITA;Atsuki NAGAO;Tatsuki OKADA;Kazuhisa SETO;Junichi TERUYAMA;Lower dietary variety is associated with worse sleep quality in community-dwelling elderly Japanese women
通讯作者：
Lower dietary variety is associated with worse sleep quality in community-dwelling elderly Japanese women

Relationship Between Social Activity and Frailty in Japanese Older Women During Restriction on Outings due to COVID-19.