The influence of gut microbiota composition and diversity on the resorption and de novo synthesis of fatty acids in the small intestine

肠道微生物群组成和多样性对小肠脂肪酸吸收和从头合成的影响

• 批准号: 316127768
• 负责人: Dr. Josef Ecker
• 金额: --
• 依托单位: Institut für Klinische Chemie und Laboratoriumsmedizin
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/316127768?language=en
• 关键词: influence; gut; microbiota; composition; diversity

The mammalian gut microbiota is a complex ecosystem, its composition and diversity depends on various factors including diet, environment, health and disease. Our preliminary data strongly indicate that gut microbiota influence absorption of dietary lipids, intestinal fatty acid trafficking, de novo synthesis and secretion into the circulation. A dysregulation of the intestinal lipid metabolism may be associated with metabolic overload. Moreover, intestinal FA synthesis may be involved in the formation of the intestinal barrier function and associated inflammatory pathologies. Gut microbiota might represent attractive targets for modulating dietary lipid resorption and intestinal lipid synthesis. Therefore, the primary objectives of this project are to investigate if and how gut microbiota composition and diversity affects the resorption of fatty acids, intestinal lipid synthesis and storage. This includes its effects on lipid composition of the intestinal barrier as well as the role of microbiota derived short chain fatty acids.

哺乳动物肠道菌群是一个复杂的生态系统，其组成和多样性取决于多种因素，包括饮食，环境，健康和疾病。我们的初步数据强烈表明，肠道微生物群影响膳食脂质的吸收、肠道脂肪酸的运输、从头合成和分泌到循环中。肠道脂质代谢失调可能与代谢超负荷有关。此外，肠FA合成可能参与肠屏障功能和相关炎症病理的形成。肠道菌群可能是调节膳食脂质再吸收和肠道脂质合成的有吸引力的目标。因此，该项目的主要目标是研究肠道微生物群的组成和多样性是否以及如何影响脂肪酸的吸收，肠道脂质的合成和储存。这包括其对肠道屏障的脂质组成的影响以及微生物群衍生的短链脂肪酸的作用。