Mechanisms underlying the effects of the gut microbiota on host liver lipid metabolism

肠道微生物群对宿主肝脏脂质代谢影响的机制

• 批准号: 281481838
• 负责人: Dr. Josef Ecker
• 金额: --
• 依托单位: Lehrstuhl für Ethnologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/281481838?language=en
• 关键词: Mechanisms; underlying; effects; gut; microbiota

The mammalian gut harbours a huge microbial community designated as gut microbiota. Based on literature findings and our preliminary data it is obvious that hepatic lipid synthesis and metabolism is influenced by gut microbiota. How the gut microbiota affects these processes remains currently unexplained and how the diet and its composition contributes to changes in the host is also not known. But, a better understanding of the bilateral relationship of host lipid metabolism and microbiota is needed for filling the gaps in human systems physiology and for any therapeutic strategies to combat related metabolic diseases and improve health. Therefore, the major objective of this project is to characterize the regulation of hepatic lipid synthesis by gut microbiota in depth. This includes the influence of the diet and to unveil molecular mechanisms involved in the regulation.

哺乳动物的肠道内有一个巨大的微生物群落，被称为肠道菌群。根据文献发现和我们的初步数据，肝脏脂质合成和代谢明显受到肠道微生物群的影响。肠道菌群如何影响这些过程目前仍无法解释，饮食及其成分如何影响宿主的变化也尚不清楚。但是，需要更好地了解宿主脂质代谢和微生物群的双边关系，以填补人体系统生理学的空白，并为对抗相关代谢疾病和改善健康提供任何治疗策略。因此，本项目的主要目的是深入表征肠道菌群对肝脂合成的调节。这包括饮食的影响和揭示参与调节的分子机制。

项目成果

Microbiome and Diseases: Metabolic Disorders

• DOI: 10.1007/978-3-319-90545-7_16
• 发表时间: 2018
• 作者: T. Clavel;J. Ecker