Nanoagents for controlled manipulation of cell-ECM interaction (B11)

细胞的集体侵袭和迁移是由细胞-细胞外基质相互作用决定的。因此，为了研究这些过程，我们将应用工具，使用我们在前一个资金期间开发的表面声波来操纵基质。此外，我们将使用上一个资助期的光遗传结构来控制细胞中的机械传感。我们将使用和改进这些工具来研究从椭球体到周围矩阵的集体入侵。

Collective cell invasion and cell migration are determined by cell-ECM interactions. To study these processes we will thus apply tools to manipulate the matrix using surface acoustic waves, which we have developed in the previous funding period. Furthermore, we will use an optogenetic construct from the last funding period to control mechanosensing in the cell. We will employ and refine those tools to investigate collective invasion from a spheroid into the surrounding matrix.