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Development of in silico model for health impact assessment of Asbestos emitted from building materials

开发用于建筑材料排放石棉健康影响评估的计算机模型

基本信息

批准号：
20KK0099
负责人：
伊藤一秀
金额：
$ 11.65万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
财政年份：
2020
资助国家：
日本
起止时间：
2020-10-27 至 2024-03-31
项目状态：
已结题

项目摘要

本研究は建築解体時に発生するアスベストの飛散と空気中濃度を必要十分な工学精度で予測した上で，アスベストの経気道曝露に伴う短期・長期の健康影響を定量的に評価するための数値気道モデルを開発する．2022年度は研究計画に従い，以下の研究課題に取り組んだ．(1)これまでに開発してきた鼻腔・口腔から気管支第4分岐までの数値気道モデルを拡張し，高精細CTデータを用いて気管支第8分岐まで再現した新たな気道モデルを作製した上で，気管支第9分岐から16分岐までを人工的なアルゴリズムにて再現した終末細気管支モデルを統合した．結果として，鼻腔・口腔から気管支第16分岐(終末細気管支)までの呼吸器詳細幾何形状を再現した数値気道モデルを作成した．(2)下気道でのアスベスト曝露解析へ適用するため，肺胞位置でのガス交換モデル(酸素－二酸化炭素交換モデル)を作製し，気管支第16分岐位置での境界条件モデルとして統合することで，鼻腔・口腔から気道を経由して肺胞位置までの全ての呼吸器要素を統合した完全呼吸器モデルを作成した．(3)鼻腔・口腔から気管支第16分岐(終末細気管支)までの呼吸器詳細幾何形状を再現した数値気道モデルを用いて，1nmから10umの広範な粒径を対象とした気道内Lagrange粒子拡散解析を実施することで，上気道から下気道まで含めた粒子沈着分布，上気道・下気道通過確率を解析し，in vivoならびにin vitro結果と比較することで解析精度を検証した．

In this study, during the disintegration of the system, it is necessary to improve the accuracy of the aircraft. in this study, it is necessary to improve the accuracy of the system during the disintegration of the aircraft. in this study, it is necessary to improve the accuracy of the system during the disintegration of the aircraft. in this study, it is necessary to improve the accuracy of the aircraft. in this study, during the disintegration of the system, it is necessary to improve the accuracy of the aircraft. it is necessary to improve the accuracy of the aircraft. in this study, it is necessary to improve the accuracy of the aircraft. in this study, during the disintegration of the system, it is necessary to improve the accuracy of the aircraft. it is necessary to increase the accuracy of the system. The following research projects are selected from the organization. (1) the fourth bifurcation of the branch of the nasal and oral cavity is used. The number of bifurcations of the fourth branch of the nasal cavity and oral cavity. The number of bifurcations of the fourth branch of the nasal cavity and the oral cavity. The number of bifurcations of the fourth branch of the nasal cavity and oral cavity, the number of branches, and the number of branches. The 9th bifurcation of the tube branch, the 16 bifurcation, the artificial tube branch, the branch, The position of the lung cell, the position of the 16th bifurcation of the tube branch, the boundary condition, the boundary condition, the position of the 16th bifurcation of the tube branch, the boundary condition, the position of the 16th bifurcation of the tube branch, the position of the 16th bifurcation of the tube branch, the boundary condition, the position of the lung cell and the position of the 16th bifurcation of the tube branch. The nasal cavity and oral cavity is made up of the lung cell position, the complete respirator elements, the complete respirator, the complete respirator. (3) the 16th bifurcation of the tube branch of the nasal cavity and oral cavity (the end of the tube branch), the shape of the respirator, the shape of the respirator, the number of the respirator, the number of the respirator, the shape of the respirator. The particle size of 1nm is similar to that of Lagrange particles in the channel, the distribution of Lagrange particles in the upper channel and the lower channel, the determination rate of the upper channel and the lower channel, the accuracy of the in vitro results show that the accuracy of the analysis is better.