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In vivo derived in silico model for DDS optimization

用于 DDS 优化的体内计算机模型

基本信息

批准号：
9127202
负责人：
Dieter Haemmerich
金额：
$ 12.54万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-25 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9127202
关键词：
3-Dimensional Adverse effects Affect Animals Applications Grants Area Bioavailable Biodistribution Biological Biological Availability Blood Vessels Blood flow Cells Complex Computer Simulation Data Development Devices Dose Doxorubicin Hydrochloride Liposome Drug Carriers Drug Delivery Systems Drug Transport Engineering Evaluation Extravasation Formulation Goals Growth Half-Life Health Heating Heterogeneity High Pressure Liquid Chromatography Human Hyperthermia Image Analysis In Vitro Kinetics Liposomes Maps Measurement Measures Methods Modeling Modification Penetration Perfusion Pharmaceutical Preparations Physiological Physiology Plasma Property Regimen Site Solid Neoplasm System Technology Temperature Testing Therapeutic Index Tissue Sample Tissues Toxic effect Tumor Biology Tumor-Derived Validation Vascular Permeabilities Work base chemotherapy contrast enhanced density design essays feeding imaging modality improved in vivo intravital fluorescence microscopy liposomal delivery liposome vector method development model design nanoparticle neoplastic cell novel novel strategies novel therapeutics quantitative imaging temporal measurement three-dimensional modeling tumor uptake

项目摘要

DESCRIPTION (provided by applicant): There are limited quantitative methods to aid systematic design and development of drug delivery systems. We have developed a computational model that predicts the amount of drug that is delivered to the tumor, and we were able to make relevant predictions for ideal properties of liposomes from our models. The first goal of this grant application is the development of methods to measure tumor transport properties in vivo. The model is then validated, and will serve as platform for optimization of heat-activated liposomal carriers. The proposed approach thus aids the development of more effective drug delivery systems, and has general applicability for various drug delivery systems.

描述（由申请人提供）：有有限的定量方法来帮助药物输送系统的系统设计和开发。我们已经开发了一个计算模型来预测输送到肿瘤的药物量，我们能够从我们的模型中对脂质体的理想特性做出相关的预测。这项拨款申请的第一个目标是开发测量体内肿瘤转运特性的方法。然后验证该模型，并将作为优化热激活脂质体载体的平台。因此，所提出的方法有助于开发更有效的药物递送系统，并且对各种药物递送系统具有普遍适用性。