课题基金 / 基金详情

In vivo derived in silico model for DDS optimization

In vivo derived in silico model for DDS optimization
用于 DDS 优化的体内计算机模型
批准号：
9127202
负责人：
Dieter Haemmerich
金额：
$12.54万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-09-25 至 2020-08-31
来源：
https://reporter.nih.gov/project-details/9127202
关键词：
3-DimensionalAdverse effectsAffectAnimalsApplications GrantsAreaBioavailableBiodistributionBiologicalBiological AvailabilityBlood VesselsBlood flowCellsComplexComputer SimulationDataDevelopmentDevicesDoseDoxorubicin Hydrochloride LiposomeDrug CarriersDrug Delivery SystemsDrug TransportEngineeringEvaluationExtravasationFormulationGoalsGrowthHalf-LifeHealthHeatingHeterogeneityHigh Pressure Liquid ChromatographyHumanHyperthermiaImage AnalysisIn VitroKineticsLiposomesMapsMeasurementMeasuresMethodsModelingModificationPenetrationPerfusionPharmaceutical PreparationsPhysiologicalPhysiologyPlasmaPropertyRegimenSiteSolid NeoplasmSystemTechnologyTemperatureTestingTherapeutic IndexTissue SampleTissuesToxic effectTumor BiologyTumor-DerivedValidationVascular PermeabilitiesWorkbasechemotherapycontrast enhanceddensitydesignessaysfeedingimaging modalityimprovedin vivointravital fluorescence microscopyliposomal deliveryliposome vectormethod developmentmodel designnanoparticleneoplastic cellnovelnovel strategiesnovel therapeuticsquantitative imagingtemporal measurementthree-dimensional modelingtumoruptake

项目摘要

项目成果

Dieter Haemmerich的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): There are limited quantitative methods to aid systematic design and development of drug delivery systems. We have developed a computational model that predicts the amount of drug that is delivered to the tumor, and we were able to make relevant predictions for ideal properties of liposomes from our models. The first goal of this grant application is the development of methods to measure tumor transport properties in vivo. The model is then validated, and will serve as platform for optimization of heat-activated liposomal carriers. The proposed approach thus aids the development of more effective drug delivery systems, and has general applicability for various drug delivery systems.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Extracorporeal Filtration of Thermosensitive Liposomes
In vivo derived in silico model for DDS optimization
In vivo derived in silico model for DDS optimization
Computational model of targeted drug delivery
海外基金