SCN2A自閉症に関する膜電位イメージングによる細胞体樹状突起シグナリングの解析

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Established a novel mouse model to study disease mechanisms underlying Scn2a neurodevelopmental disorders. For the first time, in vivo two-photo calcium imaging was performed in a Scn2a mouse model. We found that single neuron activities, as well as population co-activities were reduced in Scn2a insufficient mice during wakefulness. This may be one of the pathological mechanisms driving Scn2a neurodevelopmental disorders. Results was presented in the Japan neuroscience Society Annual Meeting and in the Okinawa Institute of Science and Technology (OIST) Internal Seminar.A manuscript is in preparation and will be submitted to a peer reviewed journal.Established collaboration opportunities between OIST and Florey Institute of Neuroscience and Mental Health, Australia.