SoftReach_Minimally-Invasive Soft-Robot-Assisted Deep-Brain Localized Therapeutics Delivery for Neurological Disorders

SoftReach_微创软机器人辅助神经系统疾病的深部脑局部治疗

• 批准号: 10062486
• 金额: $ 83.13万
• 依托单位: KING'S COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10062486
• 关键词: SoftReach_Minimally; Invasive; Soft; Robot; Assisted

Robotics and imaging can revolutionize healthcare by overcoming limitations of existing practice and enabling the clinical translation of emerging treatments. Along this direction, SoftReach focuses on improving the treatment of neurological disorders (NDs), a major unmet healthcare challenge. Despite the devastating impact of NDs to millions, existing treatments have poor efficacy. SoftReach aims to radically improve treatments by providing localized delivery of therapeutics in deep-brain regions involved in ND pathophysiology. The proposed platform can enhance the efficacy of pharmaceutical treatments by bypassing limitations of systemic delivery, and provide means to implement promising cell therapies. Our paradigm-shifting ambition will be realised through two major innovations: 1) a submillimeter soft-growing steerable robotic platform, the first of its kind, which will utilize real-time MRI feedback to navigate through the spine subarachnoid space and the Ventricular System (VS), where it will attach µl-sized payloads (carriers of therapeutics) at specific locations. 2) Novel µl-sized tissue construct payloads (TCPs), built around precisely microfabricated deployable porous scaffolds so that they can attach stably on VS walls and deliver therapeutic factors to adjacent brain regions. The platform will be demonstrated via two parallel efforts. 1) The ability of the soft-growing robot to extend via the VS and safely deliver TCPs under real-time MRI feedback will be demonstrated in high-fidelity phantoms of the human VS. 2) TCP-mediated localised delivery of treatments (compounds, cells) via the VS will be demonstrated stereotactically in mice. By providing minimally-invasive access to deep-brain regions of major clinical importance that lie beyond the reach of existing procedures, SoftReach can revolutionize the clinical practice of ND treatments and provide disrupting tools that can impact multiple fields such as gene therapy, neurosurgery and oncology

机器人技术和成像可以通过克服现有实践的局限性并实现紧急治疗的临床翻译来彻底改变医疗保健。沿着这个方向，Softreach专注于改善神经系统疾病（NDS）的治疗，这是一个主要的未经衡量的医疗挑战。尽管NDS对数百万人产生了破坏性的影响，但现有的治疗效率较差。 SOFTREACH旨在通过在参与ND病理生理学的深脑区域提供局部治疗，从而从根本上改善治疗。所提出的平台可以通过绕过系统性输送的局限性来提高药物治疗的效率，并提供实施承诺细胞疗法的手段。我们的范式转移野心将通过两项主要创新来实现：1）亚略加柔软生长的步骤的机器人平台，这是第一个同类平台，该平台将利用实时MRI反馈来浏览脊柱蛛网膜下腔空间和室心室系统（VS）（VS），在此附加µl siles payloads（the）的特定位置（cripties the Cransiers）在特定的位置（特定的位置）。 2）新型µL大小的组织构建有效载荷（TCP），围绕精确的微型可部署的多孔支架建造，以便它们可以稳定地附着在VS墙上，并将治疗因子传递到相邻的大脑区域。该平台将通过两项平行的努力进行演示。 1）软化机器人通过VS延伸并在实时MRI反馈下安全传递TCP的能力将在人类VS的高保真幻影中证明。 2）通过VS进行TCP介导的局部处理（化合物，细胞）的局部递送，将在小鼠中立体定位。通过提供最小的侵入性进入主要临床重要性的深脑区域，这超出了现有程序的范围，Softreach可以彻底改变ND治疗的临床实践，并提供破坏的工具，这些工具可能会影响基因治疗，神经外科和肿瘤学等多个领域