Proteasomal protein turnover during immune priming in Arabidopsis (C06)

该项目的目的是在分子水平上了解泛素-蛋白酶体系统（UPS）如何与细菌病原体的全身免疫反应的启动机制联系起来。在初步的工作中，我们能够表明，拟南芥突变体蛋白酶体功能受损不显示系统获得性抗性（SAR）对挑战感染细菌后，引发感染当地叶片。这些植物将在SAR期间进行详细的分子和生理分析，以鉴定和鉴定由UPS调节的防御系统反应引发的分子组分。

Aim of the project is to understand on the molecular level how the ubiquitin-proteasome system (UPS) is mechanistically linked to priming of systemic immune responses to bacterial pathogens. In preliminary work, we were able to show that Arabidopsis thaliana mutants impaired in proteasome function do not display systemic acquired resistance (SAR) towards a challenge infection with bacteria after a priming infection of local leaves. These plants will be subjected to a detailed molecular and physiological analysis during SAR to identify and characterise molecular components of the priming of defensive systemic responses that are regulated by the UPS.