Proteasomal protein turnover during immune priming in Arabidopsis (C06)

拟南芥免疫启动过程中蛋白酶体蛋白的周转 (C06)

• 批准号: 316946029
• 金额: --
• 依托单位: Leibniz-Institut für Gemüse- und Zierpflanzenbau (IGZ) e.V.
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/316946029?language=en
• 关键词: Proteasomal; protein; turnover; during; immune

Aim of the project is to understand on the molecular level how the ubiquitin-proteasome system (UPS) is mechanistically linked to priming of systemic immune responses to bacterial pathogens. In preliminary work, we were able to show that Arabidopsis thaliana mutants impaired in proteasome function do not display systemic acquired resistance (SAR) towards a challenge infection with bacteria after a priming infection of local leaves. These plants will be subjected to a detailed molecular and physiological analysis during SAR to identify and characterise molecular components of the priming of defensive systemic responses that are regulated by the UPS.

该项目的目的是在分子水平上了解泛素-蛋白酶体系统（UPS）如何与细菌病原体的全身免疫反应的启动机制联系起来。在初步的工作中，我们能够表明，拟南芥突变体蛋白酶体功能受损不显示系统获得性抗性（SAR）对挑战感染细菌后，引发感染当地叶片。这些植物将在SAR期间进行详细的分子和生理分析，以鉴定和鉴定由UPS调节的防御系统反应引发的分子组分。