The impact of copper on protein turnover

铜对蛋白质周转的影响

• 批准号: DP230101031
• 负责人: Prof Ashley Bush
• 金额: $ 42.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101031
• 关键词: impact; copper; protein; turnover

This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper action on the enzyme and its partners. Expected outcomes include an analytical understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration between experts. Potential benefits include new strategies to intervene in copper-related disorders of aging.

该项目旨在阐述研究小组的一项新发现，即一组保守的缀合酶中的保守铜结合位点促进一系列必需蛋白的泛素化，导致其快速降解，这可能是维持铜稳态的一种手段。该项目将采用一系列综合的物理化学，生物化学和细胞生物学方法来阐明这种铜对酶及其伙伴的作用的分子性质。预期成果包括对这一过程的分子机制的分析理解，以及加强专家之间的跨学科合作。潜在的好处包括干预铜相关衰老疾病的新策略。