Role of objectively measured physical activity and sedentary behavior on successful aging: population-based longitudinal study in older adults

客观测量的体力活动和久坐行为对成功老龄化的作用：基于人群的老年人纵向研究

• 批准号: 317230302
• 负责人: Professor Dr. Michael Denkinger
• 金额: --
• 依托单位: Institut für Epidemiologie und Medizinische Biometrie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317230302?language=en
• 关键词: Role; objectively; measured; physical; activity

Physical activity or mobility as a main factor of general activity is a major target in the International classification of Functioning, Disability and Health (ICF) framework to maintain or improve social participation and independent living. Strong evidence exists that physically active subjects have higher levels of physical fitness, better quality of life, and a lower risk for a variety of chronic diseases such as cardiovascular diseases, diabetes, cancer and that it is closely linked to attenuating cognitive and functional decline over time. However, data from older adults, which are at the highest risk for most of the diseases relevant in this context and in whom physical activity declines most, are still sparse. Also, longitudinal data of physical activity and sedentary behaviour trajectories in older persons based on repeated measurements are lacking. Furthermore, most available large cohort studies including older adults have estimated physical activity using retrospective questionnaires. Especially studies with repeated measurements and with longer follow-up which allow performing sensitivity analysis would help to clarify the question of possible reverse causation. The Activity Function in the Elderly in Ulm (ActiFE Ulm) study is a large cohort study in older adults with a sufficiently long follow up that included extensive accelerometer-based data on physical activity and sedentary behavior from the beginning. ActiFE Ulm is a population-based study including n=1506 older people aged 65+ years located in Southern Germany which had already been seen during an additional follow-up. During this first follow-up between August 2012 and November 2013 n=834 participants were reassessed including again a one week sensor measurement of physical activity, blood samples as well as functional, cognitive and social assessments. The objective of this proposed prospective cohort study is now to describe trajectories of physical activity and sedentary behavior in older adults during a seven year follow-up period. The assessment of physical activity and sedentary behavior will be again based on an objective measurement (accelerometer-based wearable motion detectors worn over 7 days). The prognostic association of baseline physical activity and sedentary behavior with various measures of functional status, with falls and fractures, with other morbidity (i.e. cognitive decline), with mortality rates and with specific biomarkers will be analyzed. The study will further allow identifying determinants as well as consequences of changes in physical activity and sedentary behavior patterns and trajectories. A better understanding of the health-related consequences of these patterns will enable identifying potential targets of intervention and allow a longitudinal validation of biomarkers for sedentary behavior and activity. We are confident, that our results will close existing knowledge gaps and will have important translational aspects.

身体活动或活动能力作为一般活动的主要因素，是《国际功能、残疾和健康分类》框架的一个主要目标，以保持或改善社会参与和独立生活。有强有力的证据表明，身体活动的受试者具有更高的身体健康水平，更好的生活质量，以及各种慢性疾病如心血管疾病，糖尿病，癌症的风险较低，并且随着时间的推移，它与减弱认知和功能衰退密切相关。然而，老年人的数据仍然很少，他们是大多数相关疾病的最高风险人群，身体活动减少最多。此外，缺乏基于重复测量的老年人身体活动和久坐行为轨迹的纵向数据。此外，大多数现有的大型队列研究（包括老年人）使用回顾性问卷调查估计了体力活动。特别是重复测量和长期随访的研究，允许进行敏感性分析，这将有助于澄清可能的反向因果关系的问题。乌尔姆老年人的活动功能（ActiFE乌尔姆）研究是一项在老年人中进行的大型队列研究，随访时间足够长，包括从一开始就获得的关于体力活动和久坐行为的大量基于加速计的数据。ActiFE乌尔姆是一项基于人群的研究，包括n=1506例位于德国南部的65岁以上的老年人，这些老年人已经在额外的随访中观察到。在2012年8月至2013年11月的第一次随访期间，对n=834名参与者进行了重新评估，包括再次进行为期一周的身体活动、血液样本以及功能、认知和社会评估的传感器测量。这项前瞻性队列研究的目的是描述老年人在7年随访期间的身体活动和久坐行为的轨迹。身体活动和久坐行为的评估将再次基于客观测量（基于加速度计的可穿戴运动探测器佩戴超过7天）。将分析基线体力活动和久坐行为与各种功能状态指标、福尔斯和骨折、其他发病率（即认知下降）、死亡率和特定生物标志物的预后相关性。这项研究将进一步确定身体活动和久坐行为模式和轨迹变化的决定因素和后果。更好地了解这些模式的健康相关后果将有助于确定潜在的干预目标，并允许对久坐行为和活动的生物标志物进行纵向验证。我们有信心，我们的研究结果将填补现有的知识空白，并将具有重要的转化方面。

项目成果

A prospective assessment of cardiac biomarkers for hemodynamic stress and necrosis and the risk of falls among older people: the ActiFE study

• DOI: 10.1007/s10654-015-0059-9
• 发表时间: 2016-04-01
• 期刊: EUROPEAN JOURNAL OF EPIDEMIOLOGY
• 影响因子: 13.6
• 作者: Dallmeier, Dhayana;Klenk, Jochen;Rothenbacher, Dietrich
• 通讯作者: Rothenbacher, Dietrich

Evaluation of left and right ventricular systolic and diastolic electromechanical synchrony in older people: a population-based observational study.

老年人左右心室收缩期和舒张期机电同步性的评估：一项基于人群的观察性研究

• DOI: 10.33549/physiolres.933453
• 发表时间: 2017
• 期刊: Physiological research
• 影响因子: 2.1
• 作者: Laszlo R;Konz H;Kunz K;Dallmeier D;Klenk J;Denkinger M;Koenig W;Rothenbacher D;Steinacker JM
• 通讯作者: Steinacker JM

Physical Activity and Sex Hormone-Binding Globulin in Older Adults.

老年人的体力活动和性激素结合球蛋白

• DOI: 10.1123/japa.2018-0171
• 发表时间: 2019
• 期刊: Journal of aging and physical activity
• 影响因子: 1.5
• 作者: Rothenbacher D;Dallmeier D;Denkinger MD;Boehm BO;Koenig W;Klenk J
• 通讯作者: Klenk J