Cross talk between a conjugative plasmid and its Bacillus subtilis host cell during stress adaptation (E02*)

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Conjugative plasmid pLS20 affects many cellular processes and changes the transcription of about 5% of the genes of its host, and confers considerable stress resistance during active conjugation. Conversely, the host cell affects the timing of conjugation, which is centrally regulated by a plasmid-encoded repressor controlled by a quorum-sensing Rap/Phr system. We will analyse how the cross talk between plasmid and chromosome occurs on a molecular genetic and biochemical level and how the plasmid/host systems adapt to different stress conditions.