Fundamental investigations on the effect of high effective ion temperatures on the ion mobility, cluster formation, dissociation and their dynamics as well as fragmentation by high-resolution, high kinetic energy Ion mobility spectrometry

通过高分辨率、高动能离子迁移谱分析高有效离子温度对离子淌度、团簇形成、解离及其动力学以及碎裂的影响的基础研究

• 批准号: 318063177
• 负责人: Professor Dr.-Ing. Stefan Zimmermann
• 金额: --
• 依托单位: Institut für Grundlagen der Elektrotechnik und Messtechnik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/318063177?language=en
• 关键词: Fundamental; investigations; effect; effective; ion

This project with its fundamental questions on the effect of high effective ion temperatures on the ion mobility, cluster formation, dissociation and their dynamics as well as fragmentation is intended as a consequent continuation of the Project (sign removed). At the same time, the requested continuation is an excellent complement to the ongoing Project(sign removed)on ultra-high resolution ion mobility spectrometry for the detection of even smallest differences in ion mobility. However, due to the completely different design of the ion mobility spectrometer in(sign removed), this is only possible for low reduced electric field strengths below 10 Td. Thus, the investigations with a high-energy ion mobility spectrometer (HiKE-IMS) planned in the continuation are not possible in(sign removed), which mainly concentrates on complementary investigations on monomers and dimers and in particular on the separation of isomers and enantiomers. In contrast, the focus of this continuation is on detailed experimental investigations on the effect of ion and drift gas molecular mass and effective ion temperature on the ion mobility, cluster formation, cluster dissociation and their dynamics as well as fragmentation, which are only possible with HiKE-IMS. In this context, the effect of absolute temperature and reduced electric field strength on the ion mobility at constant effective ion temperature will be also investigated. The fundamental question is whether different ion mobilities exist despite constant effective ion temperature. Furthermore, the ion mobility of different ions as a function of the reduced electric field strength at constant absolute temperature will be directly measured, which is also only possible with HiKE-IMS. These so-called alpha functions are then to be compared with the alpha functions calculated from the measurement data of a Field Asymmetric Ion Mobility Spectrometer (FAIMS) in order to investigate the dynamics of cluster transitions. For all planned experimental investigations, the required instrumentation will be developed in the continuation. Based on the findings of(sign removed), a new HiKE-IMS with a significantly higher resolving power up to 200 and a temperature stability up to 120 °C will be developed. This includes a new drift tube design, a new ion gating sequence and a controlled corona discharge source as well as the development of advanced electronics. In order to compare the alpha functions over a wide range of reduced electric field strengths up to 120 Td, the FAIMS from(sign removed)also requires significantly improved control electronics, which will be also developed.

这个项目的基本问题是，高效离子温度对离子迁移率、簇形成、解离及其动力学以及破碎的影响，旨在作为项目的后续延续（符号已删除）。同时，所要求的延续是对正在进行的超高分辨率离子迁移率光谱项目（删除符号）的极好补充，该项目用于检测离子迁移率的最小差异。然而，由于离子迁移谱仪完全不同的设计（符号删除），这只能在低于10 Td的低电场强度下实现。因此，计划在继续中使用高能离子迁移谱仪（HiKE-IMS）的研究不可能在（删除符号）中进行，主要集中在单体和二聚体的互补研究，特别是对异构体和对映体的分离。相比之下，本续的重点是对离子和漂移气体分子质量和有效离子温度对离子迁移率、簇形成、簇解离及其动力学和破碎的影响进行详细的实验研究，这些只有通过HiKE-IMS才能实现。在此背景下，还将研究在恒定的有效离子温度下，绝对温度和电场强度对离子迁移率的影响。最根本的问题是，在离子有效温度不变的情况下，是否存在不同的离子迁移率。此外，在恒定的绝对温度下，不同离子的离子迁移率作为电场强度减小的函数将被直接测量，这也是只有通过HiKE-IMS才能实现的。然后将这些所谓的α函数与场不对称离子迁移谱仪（FAIMS）测量数据计算的α函数进行比较，以研究簇跃迁的动力学。对于所有计划的实验调查，将继续开发所需的仪器。根据（符号删除）的研究结果，将开发出分辨率高达200的新型HiKE-IMS，温度稳定性高达120°C。这包括一个新的漂移管设计，一个新的离子门控序列和控制电晕放电源，以及先进的电子技术的发展。为了在高达120 Td的电场强度范围内比较α函数，FAIMS还需要显著改进控制电子设备，这也将被开发。