Further Development and Validation of MR Elastography for Assessment of the Central Cardiovascular System

用于评估中央心血管系统的磁共振弹性成像的进一步开发和验证

基本信息

项目摘要

Loss of elasticity of the vessel wall due to atherosclerosis is associated with a markedly higher risk of cardiovascular events. While it is well established that stiffness of central vessel walls is a marker of cardiovascular risk, adequate methods for assessing vessel wall stiffness are still lacking. Therefore, there is a great need for a new method that allows reliable and noninvasive measurement of changes in the stiffness of central arterial walls such as the aorta.The interdisciplinary research project proposed here is intended to continue earlier work of the applicant in cardiac MR elastography and aims at developing techniques for the visualization of the elasticity of the thoracic and abdominal aorta using MR elastography. This requires extensive new developments involving the three major components of MR elastography, i.e., the excitation method, image acquisition, and calculation of elasticity parameters. It is intended to validate the new method in healthy volunteers and patients with arterial hypertension.
由于动脉粥样硬化导致的血管壁弹性丧失与心血管事件的显著高风险相关。虽然已经确定中心血管壁的硬度是心血管风险的标志,但仍然缺乏评估血管壁硬度的适当方法。因此,非常需要一种新的方法,允许可靠的和非侵入性的测量的变化,在中央动脉壁的刚度,如主动脉,这里提出的跨学科的研究项目是为了继续在心脏MR弹性成像的申请人的早期工作,旨在开发技术的弹性可视化的胸和腹主动脉使用MR弹性成像。这需要广泛的新发展,涉及MR弹性成像的三个主要组成部分,即,激发方法、图像采集、弹性参数计算。其目的是在健康志愿者和动脉高血压患者中验证新方法。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity
Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta—Validation and Reference Values
人体胸腹主动脉稳态多频磁共振弹性成像验证和参考值
  • DOI:
    10.1097/rli.0000000000000654
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    6.7
  • 作者:
    Schaafs LA;Schrank F;Warmuth C;Steffen IG;Braun J;Hamm B;Sack I;Elgeti T
  • 通讯作者:
    Elgeti T
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Professor Dr. Thomas Elgeti其他文献

Professor Dr. Thomas Elgeti的其他文献

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