Development of a Transplantation Platform Technology Applicable for Improving Graft Survival in the Brain
开发适用于提高大脑移植物存活率的移植平台技术
基本信息
- 批准号:320041273
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2017
- 资助国家:德国
- 起止时间:2016-12-31 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Some neurodegenerative diseases, such as Parkinson’s disease, are characterized in part by a loss of a specific subtype of neuron in a specific location. It is therefore possible to consider the replacement of these cells to restore the lost function. With the advent of vastly improved cell sources (such as induced pluripotent stem cell derived neurons), it is now time to focus on overcoming the bottleneck in the transplantation process: poor graft survival. Poor cell survival post transplantation continues to be a major barrier to grafting success with survival rates typically less than 10% for fetal tissue and much lower again for stem cells. This DFG funded project (REF: NE2052/2-1) aims to tackle this problem for an entirely new and previously unexplored angle: biomaterial constructs designed to improve cell survival post transplantation. During this project we have found out that although the literature shows there is a drastic lack of oxygen in the graft core (hypoxia), stem cells can actually survive well in these conditions. We hypothesize that this is due to cells reverting to anaerobic respiration pathways. We have instead shown that glucose is a far more critical factor determining cell survival. To date, there are no glucose releasing biomaterial devices, so this project renewal is requesting funding to synthesize and characterize such materials. These would be based around encapsulation of glucose within a biodegradable poly(β-amino ester) network, using a microfluidic flow focusing device to create uniform microspheres capable of being injected through small gauge needles. Upon recommendation by Dr. Burkhard Jahnen, the original proposal (that requested four years of funding), was shortened to two years with a renewal application possible for the remaining two years. The student working on this project has been extremely hard working and productive (already working on a first author manuscript), and we are now requesting funding to add the important aspect described above to his PhD project.
一些神经退行性疾病,如帕金森病,部分特征在于特定位置的特定亚型神经元的丢失。因此,可以考虑替换这些细胞以恢复失去的功能。随着细胞来源(如诱导多能干细胞衍生的神经元)的大幅改善,现在是时候专注于克服移植过程中的瓶颈:移植物存活率差。移植后细胞存活率差仍然是移植成功的主要障碍,胎儿组织的存活率通常低于10%,干细胞的存活率也低得多。这个DFG资助的项目(REF:NE 2052/2-1)旨在从一个全新的、以前从未探索过的角度来解决这个问题:旨在提高移植后细胞存活率的生物材料结构。在这个项目中,我们发现,尽管文献显示移植物核心严重缺氧(缺氧),但干细胞实际上可以在这些条件下存活。我们假设这是由于细胞恢复到无氧呼吸途径。相反,我们已经证明葡萄糖是决定细胞存活的一个更为关键的因素。到目前为止,还没有释放葡萄糖的生物材料器械,因此该项目更新要求提供资金以合成和表征此类材料。这些将基于将葡萄糖封装在可生物降解的聚(β-氨基酯)网络内,使用微流体流动聚焦装置来产生能够通过小规格针注射的均匀微球。根据Burkhard Jahnen博士的建议,最初的提案(要求四年的资金)被缩短为两年,剩下的两年可以申请续期。从事这个项目的学生一直非常努力和富有成效(已经在第一作者手稿上工作),我们现在要求资助将上述重要方面添加到他的博士项目中。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dr. Ben Newland, Ph.D.其他文献
Dr. Ben Newland, Ph.D.的其他文献
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