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Single-cell analysis for the study of breast cancer metastasis

用于研究乳腺癌转移的单细胞分析

基本信息

批准号：
20F20112
负责人：
落谷孝広
金额：
$ 1.54万
依托单位：
Tokyo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2020
资助国家：
日本
起止时间：
2020-04-24 至 2022-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20F20112/
关键词：
Single-cell analysis Breast cancer Metastasis Single-cell RNA seq Genetic profile Cancer RNA single-cell sequence breast cancer metastasis

项目摘要

Through this collaborative research, we have obtained convincing data to say that primary Breast cancer tumors already have a small subpopulation of cells with metastatic characteristics. Results obtained by Dr. Prieto-Vila during the two years of her JSPS fellowship not only have importance in basic breast cancer research but also bear significance in treatments. Identifying metastatic cells at the early stages of cancer will be significant for the accurate treatment of the patients and an improvement in their survival.Due to the covid-19 situation, the initial steps of this research were delayed. We could not obtain clinical samples for a long time and Dr. Prieto-Vila wrote a review article at that time. For these reasons along with small complications in the single-cell analyses, the current work has not finished yet. Dr. Prieto-Vila had been working for us in the past and I hired her from now on as well, so we plan to complete this work within this fiscal year.The results so far were presented at several conferences including the 80th Annual Japanese association of Cancer as a poster presentation, and this year, in 2022 it was submitted as an oral presentation. In concrete, in one of those conferences, she met researchers from a research group in Valencia, Spain with whom we kept in contact and recently wrote an international collective collaboration.In summary, the collaborative research has been very successful with three published papers as a first author, and some other manuscripts under submission.

通过这项合作研究，我们获得了令人信服的数据，表明原发性乳腺癌肿瘤已经有一小群具有转移特征的细胞。Prieto-Vila博士在两年的JSPS奖学金期间获得的结果不仅在基础乳腺癌研究中具有重要意义，而且在治疗中也具有重要意义。在癌症的早期阶段识别转移细胞对于患者的准确治疗和提高他们的生存率将具有重要意义。由于covid-19的情况，这项研究的最初步骤被推迟。我们很长一段时间都无法获得临床样本，当时Prieto-Vila博士撰写了一篇综述文章。由于这些原因，沿着单细胞分析中的小的复杂性，当前的工作尚未完成。Prieto-Vila博士过去一直为我们工作，从现在开始我也雇用了她，所以我们计划在本财政年度内完成这项工作。到目前为止，该成果已在第80届日本癌症协会年会上作为海报展示，今年，在2022年作为口头展示提交。具体来说，在其中一次会议上，她遇到了西班牙瓦伦西亚的一个研究小组的研究人员，我们一直与他们保持联系，最近撰写了一份国际集体合作。总之，合作研究非常成功，作为第一作者发表了三篇论文，还有一些手稿正在提交中。