Train the brain with music: Brain Plasticity and cognitive benefits induced by musical practice in elderly people in Germany and Switzerland

用音乐训练大脑：德国和瑞士老年人音乐练习带来的大脑可塑性和认知益处

• 批准号: 323965454
• 负责人: Professor Dr. Eckart Altenmüller
• 金额: --
• 依托单位: Facultè de Psychologie et des Sciences de IEducation
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/323965454?language=en
• 关键词: Train; brain; music; Brain; Plasticity

Recent data suggest that music making might prevent cognitive decline in the elderly. However, experimental evidence remains sparse and no information on the neurophysiological basis has been provided, although cognitive decline is a major impediment to healthy aging. This study combines for the first time protocolled music practice in elderly with cutting-edge neuroimaging. We propose a multi-site Hannover-Geneva longitudinal randomized intervention study in altogether 100 retired healthy elderly (64-76) years, 40 Geneva, 60 Hannover), offering either piano instruction or instruction on music history and music theory for one year. Subjects will be tested at 3 time points on cognitive, perceptual and motor abilities as well as via wide-ranging functional and structural neuroimaging data (Magnetic Resonance Imaging, MRI). We expect positive transfer effects from intensive piano training not only on subjective well-being, but also on executive functions, working memory, hearing in noise and relationships of these behavioral features with morphological and functional brain plasticity. We may therefore for the first time demonstrate, that music making can provoke important societal impacts by diminishing cognitive and perceptual-motor decline underpinned by functional and structural brain plasticity. Not only does this project assemble a unique combination of expertise in music science, neurology, psychology, gerontology and (f)MRI data analyses, but moreover, the multisite approach will enhance statistical power and allow broader generalization of results.

最近的数据表明，音乐制作可能会防止老年人的认知能力下降。然而，尽管认知能力下降是健康老龄化的一个主要障碍，但实验证据仍然很少，也没有提供关于神经生理学基础的信息。这项研究首次将老年人的音乐练习与尖端的神经成像技术结合起来。我们提出一项多中心的汉诺威-日内瓦纵向随机干预研究，共100名退休健康老年人（64-76岁，日内瓦40人，汉诺威60人），提供钢琴教学或音乐史和音乐理论教学一年。将在3个时间点对受试者的认知、知觉和运动能力以及通过广泛的功能和结构神经成像数据（磁共振成像，MRI）进行测试。我们期望积极的转移效果，从密集的钢琴训练不仅对主观幸福感，而且对执行功能，工作记忆，听力在噪音和这些行为特征与形态和功能的大脑可塑性的关系。因此，我们可能首次证明，音乐制作可以通过减少由功能和结构大脑可塑性支持的认知和感知运动衰退来引发重要的社会影响。该项目不仅汇集了音乐科学，神经学，心理学，老年学和（f）MRI数据分析方面的专业知识，而且，多站点方法将增强统计能力，并允许更广泛地推广结果。