Towards a New Bone Scaffold Material - Exploring Silicon Nanowires as a Biomimetic Environment for Osteoblastic Differentiation

迈向新型骨支架材料——探索硅纳米线作为成骨细胞分化的仿生环境

• 批准号: 325743178
• 负责人: Dr. Annina Steinbach
• 金额: --
• 依托单位: Institut für Elektronische Bauelemente und Schaltungen (EBS)
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/325743178?language=en
• 关键词: Towards; New; Bone; Scaffold; Material

The goal of the proposed project is the development of silicon nanowire tissue-like fleeces as a novel scaffold material for bone tissue engineering. The material promises the synergistic effect of a biomimetic structure and the chemical release of silicate as a factor for enhancing bone build-up. The project will comprise material synthesis, acellular characterisation of the material and in vitro characterisation in a mesenchymal stem cell (MSC) model to optimise the material and maximise its potential to induce osteogenic differentiation and candidacy for translation.By using silicon nanowire fleeces not only a synergistic effect of structure and chemistry might be induced but it also offers the unique possibility to independently control diameter, length and branching of the individual fibrous structures without changing bulk or surface chemistry. Additionally, silicon nanowire fleeces without a support substrate, representing a new class of material, will be fabricated to offer a hierarchical 3-dimensional environment for cells with the aim to mimic bone matrix structurally.Mineralisation of the silicon nanowire fleeces with strontium-doped calcium phosphate will provide a composite material that merges several factors for successful osseoinduction: silicate, calcium, phosphate and strontium ion release combined with a biomimetic structure. Several strategies for material synthesis exist and the host institution offers a wealth of ground-breaking methods specially tailored to gain information on nanomaterials and analyse the cellular reaction to the resulting material.

该项目的目标是开发硅纳米线组织状绒毛作为一种新型的骨组织工程支架材料。这种材料承诺了仿生结构和硅酸盐化学释放的协同效应，作为促进骨积累的因素。该项目将包括材料合成、材料的去细胞特性以及在间充质干细胞(MSC)模型中的体外特性，以优化材料并最大限度地发挥其诱导成骨分化和候选翻译的潜力。通过使用硅纳米线绒毛，不仅可以诱导结构和化学的协同效应，而且它还提供了独特的可能性，在不改变体积或表面化学的情况下独立控制单个纤维结构的直径、长度和分支。此外，无支撑衬底的硅纳米线绒毛代表了一种新的材料类别，将为细胞提供分层的三维环境，目的是在结构上模仿骨基质。将硅纳米线绒毛与锶掺杂的磷酸钙进行矿化将提供一种复合材料，它融合了几种成功诱导成骨的因素：硅酸盐、钙、磷和锶离子的释放以及仿生结构。有几种材料合成战略，主办机构提供了大量专门为获得纳米材料信息和分析细胞对所产生材料的反应而量身定做的开创性方法。

项目成果

The Electronic Properties of Silicon Nanowires during Their Dissolution under Simulated Physiological Conditions

• DOI: 10.3390/app9040804
• 发表时间: 2019-02
• 期刊: Applied Sciences
• 作者: A. Steinbach;T. Sandner;Madeleine Nilsen;Ximeng Hua;R. Sivakumar;D. Geiger;A. Moeinian;S. Strehle