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Multidimensional fast gas chromatography on basis of flow-field thermal gradient gas chromatography

基于流场热梯度气相色谱的多维快速气相色谱

基本信息

批准号：
326648191
负责人：
Privatdozent Dr. Peter Boeker
金额：
--
依托单位：
Institut für Landtechnik (ILT)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2017
资助国家：
德国
起止时间：
2016-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/326648191?language=en
关键词：
Multidimensional fast gas chromatography basis

项目摘要

The project within the framework of the program New devices for research is aimed at the development of a new type of fast multidimensional gas chromatography. Currently the measurements are made with complex measurement systems whose data are and difficult to interpret. This prevents a broad adoption of this technology in basic research. The new gas chromatographic method will be fast and easy to use. In different areas of basic research a more differentiated look on chemical complexity will be established. Furthermore, dynamic processes can be observed by the fast cycling measurement system. New research over extensive sample numbers becomes possible. In classical gas chromatography co-elution is frequent, especially in fast and low resolution measurements. Two dimensional gas chromatography suppresses co-elution with two successive columns and two different separation mechanisms. Two different methods are established. With heart-cutting GC selected time intervals from the first dimension separation are cut to the second dimension column. In comprehensive GC, or GCxGC, the whole first dimension separation is modulated in very short time intervals and separated on a short and fast second column. The proposal describes an alternative approach which has some advantages compared to the present state-of-the-art. It is based on a new basic technology, the flow-field thermal gradient gas chromatography. This separation method yields high resolution in short cycles even below one minute. The thermal gradient focuses the signals, the modified chromatographic transport lowers elution temperatures substantially. Therefore the application range of GC is expanded. The conceptual and technical simplicity makes FF-TG-GC an ideal module for multidimensional gas chromatographic set-ups. The basic idea is the coupling of two FF-TG-GC systems. The sample mixtures are separated on a short first column in an intermittent way. This has become possible with the very fast cooling flow-field principle. By valveless switching (e.g. a Deans switch) the eluates are directed to the second column. Here, complete temperature and gradient programmed separation on an orthogonal column takes place in the thermal gradient mode.

研究新设备计划框架内的项目旨在开发一种新型的快速多维气相色谱。目前，这些测量都是用复杂的测量系统进行的，这些测量系统的数据复杂且难以解释。这阻碍了这项技术在基础研究中的广泛采用。新的气相色谱方法将是快速和易于使用的。在基础研究的不同领域，将建立对化学复杂性的更有区别的看法。此外，该快速循环测量系统还可以观察到动态过程。对大量样本进行新的研究成为可能。在经典的气相色谱中，共洗脱是很常见的，特别是在快速和低分辨率的测量中。二维气相色谱通过两个连续的柱和两种不同的分离机制来抑制共洗脱。建立了两种不同的方法。对于令人心碎的GC，从第一维分离中选择的时间间隔被剪切到第二维列。在综合GC或GCxGC中，整个第一维分离以非常短的时间间隔进行调制，并在短而快的第二柱上分离。该提案描述了一种替代方法，与目前最先进的方法相比具有一些优势。它是基于一种新的基础技术--流场热梯度气相色谱。这种分离方法在短周期内获得高分辨率，甚至不到一分钟。温度梯度集中了信号，改进的色谱传输大大降低了洗脱温度。从而扩大了GC的应用范围。概念和技术的简单性使FF-TG-GC成为多维气相色谱装置的理想组件。其基本思想是两个FF-TG-GC系统的耦合。样品混合物以间歇方式在短的第一柱上分离。这已经成为可能，因为有了非常快的冷却流场原理。通过无阀切换(例如迪恩斯开关)，洗脱液被引导至第二柱。在这里，正交柱上的完全温度和梯度程序分离是在热梯度模式下进行的。