Diet influences the selective advantage of mitochondrial DNA mutations

饮食影响线粒体 DNA 突变的选择优势

• 批准号: DP160102575
• 负责人: Prof Bill Ballard
• 金额: $ 21.97万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102575
• 关键词: Diet; influences; selective; advantage; mitochondrial

This project aims to examine critical mechanisms that affect mitochondrial DNA variation within species. It aims to test the hypothesis that mitochondrial DNA haplotypes have the potential to be under nutritionally induced balancing selection as a consequence of cellular signalling and/or Adenosine triphosphate (ATP) production by mitochondria. Diet can vary both seasonally and geographically and is a key environmental parameter that influences the ability of a species to colonise new habitats. The project plans to characterise the functional links between specific mitochondrial DNA haplotypes, mitochondrial functions and organismal traits. The expected outcome is a more precise grasp of the processes influencing genetic variation within and among species, which would inform current issues in ecology and genetics.

该项目旨在研究影响物种内线粒体DNA变异的关键机制。该研究旨在验证线粒体DNA单倍型可能由于细胞信号传导和/或线粒体产生三磷酸腺苷（ATP）而导致营养诱导的平衡选择。饮食可以随季节和地理变化而变化，是影响物种殖民新栖息地能力的关键环境参数。该项目计划描述特定线粒体DNA单倍型、线粒体功能和有机体特征之间的功能联系。预期的结果是更精确地掌握影响物种内部和物种之间遗传变异的过程，这将为当前的生态学和遗传学问题提供信息。