Non-invasive inverstigations of indicators for an increased risk of developing metabolic syndrome in 6- to 7-year-old children born very preterm

对 6 至 7 岁极早产儿患代谢综合征风险增加的指标进行无创调查

• 批准号: 33279219
• 负责人: Dr. Eva Landmann
• 金额: --
• 依托单位: Abteilung für Allgemeine Pädiatrie und Neonatologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/33279219?language=en
• 关键词: Non; invasive; inverstigations; indicators; increased

Low birth weight in infants born at term is associated with an increased risk of developing metabolic syndrome in later life. Intrauterine malnutrition is assumed to lead to permanent metabolic adaptations resulting in insulin resistance and associated disorders. To date, it has been scarcely studied whether children born very preterm are also at an increased risk for developing metabolic syndrome. Just like term infants born with a low birth weight due to fetal malnutrition during the last trimester of intrauterine life, preterm infants face an adverse environment postnatally during a developmental stage which corresponds to the third trimester of a normal pregnancy. This situation might equally lead to lifelong programming of endocrine-metabolic pathways. We hypothesize that children born very preterm are at increased risk of developing metabolic syndrome. In a prospective study we therefore aim to study a whole spectrum of surrogate parameters for risk of developing metabolic syndrome in 6- to 7-year-old children. Between 6- to 7-year-old children born at term and those born preterm we aim to compare insulin sensitivity, blood pressure, vascular resistance, body composition, visceral adipose tissue, and adrenal androgen production using modern non-invasive methods.

足月出生的婴儿出生体重低与晚年患代谢综合征的风险增加有关。宫内营养不良被认为会导致永久性代谢适应，从而导致胰岛素抵抗和相关疾病。迄今为止，很少有人研究早产儿是否也会增加患代谢综合征的风险。就像足月儿出生时由于胎儿营养不良而导致出生体重偏低一样，早产儿在出生后的发育阶段（相当于正常妊娠的第三个月）也面临着不利的环境。这种情况同样可能导致内分泌代谢途径的终身编程。我们假设早产儿患代谢综合征的风险增加。因此，在一项前瞻性研究中，我们的目标是研究6至7岁儿童发生代谢综合征风险的整个替代参数谱。在6- 7岁足月出生和早产儿之间，我们的目的是使用现代非侵入性方法比较胰岛素敏感性、血压、血管阻力、身体成分、内脏脂肪组织和肾上腺雄激素的产生。