新規C-Hスルホンアミド化反応が可能にする植物気孔の開閉メカニズム研究

新型C-H磺酰胺化反应植物气孔开闭机制研究

• 批准号: 19J23677
• 负责人: Yip Shu Jan
• 金额: $ 2.18万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-25 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19J23677/
• 关键词: スルホンアミド; イミダゾロン; 気孔; アラビドプシス; Sulfonamide; Imidazolone; Stomata; Arabidopsis

Stomata are microscopic pores found on the epidermal of most ground plants. They play crucial roles in regulating water loss and allowing for gaseous exchange with the atmosphere. Our group have previously discovered a sulfonamide molecule, SIM1*, that exhibited bioactivity in inhibiting the opening of stomata. However, the synthesis of SIM1* requires multi-steps, and this research was focused on the development of a direct synthesis of SIM1* derivatives. During reaction screening, we serendipitously discovered a new and unique double-sulfonaminated imidazolone molecule, AYSJ929, that was found to exhibit bioactivity in decreasing the number of stomata in Arabidopsis thaliana. AYSJ929 is therefore a promising candidate that could help further understand stomatal development.

气孔是在大多数地面植物的表皮上发现的微观孔隙。它们在调节水分流失和允许与大气进行气体交换方面发挥着至关重要的作用。我们的小组先前发现了一种磺胺分子，SIM 1 *，其在抑制气孔开放方面表现出生物活性。然而，SIM 1 * 的合成需要多个步骤，并且本研究集中于开发SIM 1 * 衍生物的直接合成。在反应筛选过程中，我们偶然发现了一个新的和独特的双磺酰胺咪唑啉酮分子，AYSJ929，被发现在减少拟南芥气孔的数量中表现出生物活性。因此，AYSJ929是一个有希望的候选人，可以帮助进一步了解气孔发育。