SPP 1316: Host-adapted Metabolism of Bacterial Pathogens

SPP 1316：细菌病原体的宿主适应代谢

• 批准号: 33588101
• 金额: --
• 依托单位: Arbeitsgruppe Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/33588101?language=en
• 关键词: SPP; 1316; Host; adapted; Metabolism

What enables bacteria to proliferate with their host organisms and to cause disease? To answer this question, it is not sufficient to understand the function of specific virulence determinants such as toxins or invasins. Traditionally, the interaction with the host defense has been defined as the basis microbial pathogenicity, leading to the characterisation of defensive and offensive virulence determinants. More recently, it became obvious that the co-evolution of host and pathogen also resulted in an adaptation of the metabolism of the pathogen. Examples are "fitness factors" such as iron uptake systems or the reduction or extension of metabolic pathways. Recently developed highly sensitive bioanalytical techniques now allow the in-depth study of the adaptation of the pathogen's metabolism to the host organism. In the framework of this Priority Pogramme researchers will investigate how bacterial pathogens adapt their metabolism during colonisation of host organisms, how the metabolism of pathogenic bacteria and host organism is interconnected and which mechanisms of control are active. Projects in this Priority Pogramme aim to identify metabolic pathways that are important for the bacteria during infection and to determine the metabolic fluxes. The metabolic reactions of the host organisms and the genetic mechanisms of metabolic adaptation will be unraveled. Specific aims of the programme are:

是什么使细菌能够与其宿主生物一起增殖并引起疾病？要回答这个问题，了解特定毒力决定因子（如毒素或侵袭素）的功能是不够的。传统上，与宿主防御的相互作用被定义为微生物致病性的基础，导致防御性和进攻性毒力决定因素的特征。最近，很明显，宿主和病原体的共同进化也导致了病原体代谢的适应。例如，“健康因素”，如铁吸收系统或代谢途径的减少或延长。最近开发的高度敏感的生物分析技术现在允许深入研究病原体的代谢适应宿主生物体。在这个优先方案的框架内，研究人员将研究细菌病原体如何在宿主生物体的定植过程中适应其代谢，病原菌和宿主生物体的代谢如何相互关联，以及哪些控制机制是活跃的。这个优先项目的目的是确定在感染过程中对细菌重要的代谢途径，并确定代谢通量。宿主生物的代谢反应和代谢适应的遗传机制将被揭开。该方案的具体目标是：