Erforschung der energiehomöostatischen Rolle von Transthyretin im Kontext von Fettleibigkeit, Diabetes und Metabolischem Syndrom

探索运甲状腺素蛋白在肥胖、糖尿病和代谢综合征背景下的能量稳态作用

• 批准号: 33935013
• 负责人: Privatdozent Dr. Daniel Kraus
• 金额: --
• 依托单位: Schwerpunkt für Nephrologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/33935013?language=en
• 关键词: Erforschung; der; energiehom; ostatischen; Rolle

Dysregulation of energy balance leads to diabetes and obesity. It has assumed alarming proportions worldwide. Energy homeostasis is controlled to a high degree by adipokines, hormones produced by fat cells. Recently, the adipokine retinol-binding protein 4 (RBP4) has been identified. It provides a link between fat tissue and systemic energy balance. Transthyretin (TTR) is the transport protein for RBP4 in the bloodstream and delays its renal excretion. The role of transthyretin itself in energy homeostasis however is currently unclear. The current project aims at elucidating transthyretin’s effects on glucose metabolism and the maintenance of body weight. Genetically modified mouse models will be used to investigate insulin and glucose metabolism in different dietary conditions. The in vivo experiments will be comple-mented by in vitro analyses of insulin signaling and adipokine production in specific tissues. The results of these studies may yield important insights into the physiology of energy metabolism and reveal novel perspectives for therapeutic approaches to a significant medical problem.

能量平衡失调会导致糖尿病和肥胖。它在世界范围内的比例令人震惊。能量稳态在很大程度上是由脂肪细胞产生的激素脂肪因子控制的。最近，人们发现了脂肪因子视黄醇结合蛋白4 （RBP4）。它提供了脂肪组织和系统能量平衡之间的联系。转甲状腺素（TTR）是血液中RBP4的转运蛋白，并延迟其肾脏排泄。然而，转甲状腺素本身在能量稳态中的作用目前尚不清楚。目前的项目旨在阐明转甲状腺素对葡萄糖代谢和体重维持的影响。转基因小鼠模型将用于研究不同饮食条件下的胰岛素和葡萄糖代谢。体内实验将通过在体外分析特定组织中胰岛素信号和脂肪因子的产生来补充。这些研究的结果可能会对能量代谢的生理学产生重要的见解，并为解决重大医学问题的治疗方法提供新的视角。