Neurophysiological investigations for the clinical usability of endogeneously modulated ECoG signals from striate and extrastriate visual cortex by estimating the focus of attention at the level single trials

通过估计单次试验水平的注意力焦点，对来自纹状体和纹状体外视觉皮层的内源性调节 ECoG 信号的临床可用性进行神经生理学研究

• 批准号: 341162354
• 负责人: Dr. Detlef Wegener
• 金额: --
• 依托单位: Abteilung Theoretische Neurobiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/341162354?language=en
• 关键词: Neurophysiological; investigations; clinical; usability; endogeneously

The transfer of knowledge about the functional dynamics of neuronal population activity from basic neuroscience to clinical applications is a central goal for systems neuroscience. Multielectrode arrays play an important role in this process, since they have a high potential for clinical applications that depend on spatiotemporally highly resolved neuronal activity patterns, and are easy to implant. In the current project, newly invented multielectrode arrays will be used to record ECoG signals from primary visual cortex and to identify the focus of attention in data fragments of a few hundred milliseconds utilizing methods from machine learning. The project aims to a) acquire the basic knowledge of the information content of ECoG signals and their attention-dependent modulation for the detection of the attentional focus in single trials from early visual cortex, b) apply this knwledge for developing a fast and easy communication method for patients suffering from locked-in sydrome, and c) gain better knowledge on the long-term usability of chronically implanted multielectrode arrays and the efficient analysis of ECoG signals for clinical purposes.

将神经元群体活动的功能动力学知识从基础神经科学转移到临床应用是系统神经科学的中心目标。多电极阵列在这一过程中发挥了重要作用，因为它们具有很高的潜力，依赖于时空高度分辨的神经元活动模式的临床应用，并且易于植入。在目前的项目中，新发明的多电极阵列将用于记录来自初级视觉皮层的ECoG信号，并利用机器学习方法在几百毫秒的数据片段中识别注意力的焦点。该项目旨在a）获得ECoG信号的信息内容及其注意力依赖性调制的基本知识，用于在早期视觉皮层的单次试验中检测注意力焦点，B）应用该知识为患有闭锁综合征的患者开发快速简便的通信方法，以及c）更好地了解长期植入的多电极阵列的长期可用性以及用于临床目的的ECoG信号的有效分析。