Elucidation of the molecular mechanism of lipid-sensing by the novel SREBP-1 protease R4

新型SREBP-1蛋白酶R4阐明脂质传感的分子机制

• 批准号: 19K11713
• 负责人: Han Song-iee
• 金额: $ 2.75万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K11713/
• 关键词: SREBP-1; protease; 脂肪酸; プロテアーゼ; lipid-sensing

项目成果

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice

糖尿病 db/db 小鼠胰岛血管对胰岛素抵抗的形态和功能适应受损

• DOI: 10.1016/j.bbadis.2022.166339
• 发表时间: 2022
• 期刊: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 作者: Okajima Yuka;Matsuzaka Takashi;Miyazaki Shun;Motomura Kaori;Ohno Hiroshi;Sharma Rahul;Shimura Takuya;Istiqamah Nurani;Han Song-iee;Mizunoe Yuhei;Osaki Yoshinori;Iwasaki Hitoshi;Yatoh Shigeru;Suzuki Hiroaki;Sone Hirohito;Miyamoto Takafumi;Aita Yuichi;Takeu
• 通讯作者: Takeu

新規プロテアーゼによるSREBP-1活性化制御機構の解明

阐明新型蛋白酶控制 SREBP-1 激活的机制

• 发表时间: 2020
• 作者: 韓 松伊;中川嘉;宮本崇史;松坂賢;関谷元博;島野仁
• 通讯作者: 島野仁

Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling

饥饿诱导的转录因子 CREBH 通过控制 GH 信号传导负调控身体生长

• DOI: 10.1096/fj.202002784rr
• 发表时间: 2021
• 期刊: The FASEB Journal
• 作者: Nakagawa Yoshimi;Kumagai Kae;Han Song‐iee;Mizunoe Yuhei;Araki Masaya;Mizuno Seiya;Ohno Hiroshi;Matsuo Kazuya;Yamada Yasunari;Kim Jun‐dal;Miyamoto Takafumi;Sekiya Motohiro;Konishi Morichika;Itoh Nobuyuki;Matsuzaka Takashi;Takahashi Satoru;Sone Hirohito;Shi
• 通讯作者: Shi

Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations

• DOI: 10.3390/ijms21010361
• 发表时间: 2020-01-01
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Kawasaki, Mayu;Kambe, Akira;Shimano, Hitoshi
• 通讯作者: Shimano, Hitoshi

Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes

• DOI: 10.1038/s41598-020-57428-6
• 发表时间: 2020-01-20
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Mizunoe, Yuhei;Kobayashi, Masaki;Higami, Yoshikazu
• 通讯作者: Higami, Yoshikazu