Reg growth factors in gastric regeneration and disease

Reg生长因子在胃再生和疾病中的作用

• 批准号: DP0662959
• 负责人: A/Prof Ian van Driel
• 金额: $ 18.98万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0662959
• 关键词: Reg; growth; factors; gastric; regeneration

This project will obtain a more detailed knowledge of the role that growth factors play in helping the lining of the stomach repair itself after damage caused by disease. Growth factors may also play a role in causing stomach cancer. To do this we will examine the expression of growth factors in number of stomach diseases and cancer and assay the ability of growth factors to promote the growth of stomach cells. This work is that it will contribute to our knowledge of how cell growth in the stomach is controlled under normal circumstances and in the very common pathological conditions of tissue damage, inflammation and cancer. It may also help us understand how inflammation can in some circumstances lead to cancer.

该项目将更详细地了解生长因子在帮助胃内壁因疾病造成损伤后进行自我修复方面所发挥的作用。生长因子也可能在导致胃癌中发挥作用。为此，我们将检查生长因子在多种胃病和癌症中的表达，并测定生长因子促进胃细胞生长的能力。 这项工作将有助于我们了解在正常情况下以及在组织损伤、炎症和癌症等非常常见的病理条件下如何控制胃中的细胞生长。 它还可以帮助我们了解炎症在某些情况下如何导致癌症。