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Characterization of the plant mitochondrial twin arginine translocation pathway

植物线粒体双精氨酸易位途径的表征

基本信息

批准号：
350182520
负责人：
Privatdozent Dr. Christopher Carrie, Ph.D.
金额：
--
依托单位：
School of Biological Sciences
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2017
资助国家：
德国
起止时间：
2016-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/350182520?language=en
关键词：
Characterization plant mitochondrial twin arginine

项目摘要

Twin arginine translocation (Tat) pathways have been extensively studied in bacteria and chloroplasts and have essential roles in photosynthesis, energy metabolism and iron and phosphate metabolism. Tat pathways are extremely interesting as they transport fully folded proteins into and across membranes. This is in contrast to other transport pathways which transport proteins in an unfolded state. Our recent data indicate that plant mitochondria also contain a potential Tat pathway. It could be demonstrated that this pathway is essential for plant mitochondrial biogenesis and by extension is essential for plant growth and development. However, to date only one substrate was identified for the pathway and the exact reason as to why the pathway is essential is still an open question. The proposed project seeks to further dissect the exact roles and mechanisms of the plant mitochondrial Tat pathway. Investigations will include identifying the exact substrates of the mitochondrial Tat pathway, what role it plays in plant mitochondrial biogenesis, and finally the subunits required for its activity. One final evolutionary question to answer is why do plant mitochondria require a Tat pathway, while the mitochondria of other organisms like yeast and humans do not contain a Tat pathway.

双精氨酸转运（达特）途径在细菌和叶绿体中被广泛研究，并在光合作用、能量代谢、铁和磷代谢中起重要作用。达特途径是非常有趣的，因为它们运输完全折叠的蛋白质进入和穿过膜。这与以未折叠状态运输蛋白质的其他运输途径相反。我们最近的数据表明，植物线粒体也包含一个潜在的达特途径。可以证明，该途径是植物线粒体生物合成所必需的，并且通过延伸是植物生长和发育所必需的。然而，到目前为止，只有一个底物被确定为途径和确切的原因，为什么途径是必不可少的仍然是一个悬而未决的问题。该项目旨在进一步剖析植物线粒体达特途径的确切作用和机制。调查将包括确定线粒体达特途径的确切底物，它在植物线粒体生物合成中起什么作用，最后是其活性所需的亚基。最后一个需要回答的进化问题是，为什么植物线粒体需要达特通路，而其他生物如酵母和人类的线粒体不包含达特通路。