Anodic and Cathodic Formation of Heterocyclic Compounds and Intermolecular Coupling by N-X Bond Formation

N-X键的形成在许多生物学和技术相关的杂环的合成中是重要的关键步骤。传统方法存在缺点，例如需要金属、剧烈的反应条件和有毒试剂。因此，我们希望利用项目资金研究一种更安全，更具有生态和经济可持续性的反应途径，采用电化学方法构建N-X键。一般来说，电化学使两种不同的方法：以前获得的经验，关于氧化偶联与酰胺基自由基将有利于目标，以合成药物和生物活性物质类，如吲唑酮，异恶唑啉和异噻唑。此外，多重键参与喹诺酮和吲哚的合成将进行研究。此外，分子间的N-N键的形成将被阐明，以获得重要的杂环结构单元。N-X键形成的还原方案的包括和利用完善了电化学的应用范围，并提供了重要的氮杂环的接入点。基于不同的硝基化合物，旨在通过分子间和分子内偶联建立物质类别如吲哚、三唑、恶二唑和三嗪的路线。

The N-X bond formation holds an important key step in the synthesis of many biologically and technically relevant heterocycles. Classical methods exhibit disadvantages, such as the requirement of metals, drastic reaction conditions, and toxic reagents. Therefore, we would like to use the project funding to investigate a reaction pathway, which is safer and of higher ecological and economical sustainability, that employs electrochemical means to construct N-X bonds. Generally, electrochemistry enables two different approaches: Previously acquired experience regarding the oxidative coupling with amidyl radicals will benefit the objective to synthesize pharmaceutical and bioactive substance classes, such as indazolones, isoxazolines and isothiazoles. In addition, the involvement of multiple bonds for the synthesis of quinolones and indoles will be investigated. Furthermore, the intermolecular formation of N-N bonds will be elucidated in order to obtain important building blocks for heterocycles. The inclusion and utilization of reductive protocols for N-X bond formation completes the application spectrum of electrochemistry and provides an access point to important nitrogen heterocycles. Based on different nitro compounds, a route to substance classes such as indoles, triazoles, oxadiazoles and triazines is intended, established by inter- and intramolecular coupling.