The functional role of labilization and reconsolidation for memory formation during sleep and wakefulness

睡眠和清醒期间不稳定和再巩固对记忆形成的功能作用

• 批准号: 355641282
• 负责人: Privatdozentin Dr. Susanne Diekelmann, Ph.D.
• 金额: --
• 依托单位: Consejo Nacional de Investigaciones Científicas y Técnicas
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/355641282?language=en
• 关键词: functional; role; labilization; reconsolidation; memory

This project will examine the functional role of labilization and reconsolidation processes during sleep and wakefulness for the adaptive formation and modification of memories for the long term. Understanding how memories are formed and how they can be modified is essential not only for optimal pedagogical applications but also for the development of new treatments for disorders involving distorted or traumatic memories. In the first part of the project, we will study the neuronal and electrophysiological underpinnings of reactivation-induced labilization and reconsolidation during sleep and wakefulness, applying fMRI combined with polysomnography, as well as EEG analyses of ERPs and oscillatory activity. The second part of the project will focus on the direct manipulation of labilization and reconsolidation process in the sleep and wake state by means of pharmacological interventions, specifically targeting the GABAergic system by application of the benzodiazepine-like Zolpidem. Both parts will be run in close collaboration between the Argentinean and the German partners (focusing on the first and second part, respectively), fruitfully combining the complementary expertise of both parties.

这个项目将研究在睡眠和觉醒过程中不稳定和重新巩固过程的功能作用，以适应长期记忆的形成和修改。了解记忆是如何形成的，以及它们是如何被修改的，不仅对于最佳的教学应用至关重要，而且对于开发涉及扭曲或创伤性记忆的疾病的新疗法也至关重要。在该项目的第一部分，我们将研究在睡眠和觉醒过程中再激活诱导的不稳定和再巩固的神经和电生理基础，应用功能磁共振成像结合多导睡眠图，以及脑电图分析ERPs和振荡活动。该项目的第二部分将侧重于通过药物干预直接操纵睡眠和清醒状态下的不稳定和再巩固过程，特别是通过应用苯二氮卓类唑吡坦靶向GABA能系统。这两个部分将在阿根廷和德国合作伙伴之间密切合作（分别侧重于第一和第二部分），有效地结合双方的互补专业知识。