Sleep to be social: Sleep-dependent processing of social information about the self and others

睡眠具有社交性：依赖睡眠的有关自我和他人的社交信息的处理

• 批准号: 420599815
• 负责人: Privatdozentin Dr. Susanne Diekelmann, Ph.D.
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/420599815?language=en
• 关键词: Sleep; social; dependent; processing; information

The learning and abstraction of social information from complex and highly dynamic social interactions is a central human capacity. In order to navigate the social environment, human beings need to understand others’ behaviors and at the same time adapt their own behavior based on social feedback. Processing and abstraction of social gist-like information thereby has an essential function in various domains of social behavior. The overarching goal of this proposal is to study the functional role of human sleep in the processing of social information about oneself and others and what is abstracted during sleep as gist from such complex social information. Specifically, we aim to show that learning of social information about oneself and others is enhanced through sleep-dependent memory consolidation and that such enhancement will be stronger than for the processing of non-social information. We will further show how these processes can be modified by manipulating the reactivation of information about oneself, others or a non-social computer algorithm during sleep via learning-associated cues. Finally, we will reveal the neural mechanisms underlying sleep-dependent memory consolidation of social information. The findings of this project will open new avenues for sleep-based treatments in patients who suffer from disorders of social information processing, e.g. in Autism Spectrum Disorder, Borderline Personality or Social Anxiety Disorders.

从复杂且高度动态的社交互动中学习和抽象社会信息是人类的核心能力。为了驾驭社会环境，人类需要理解他人的行为，同时根据社会反馈调整自己的行为。因此，社会要点信息的处理和抽象在社会行为的各个领域中具有重要的功能。该提案的总体目标是研究人类睡眠在处理有关自己和他人的社会信息中的功能作用，以及在睡眠期间从这些复杂的社会信息中抽象出什么要点。具体来说，我们的目的是表明，通过依赖睡眠的记忆巩固，可以增强对自己和他人的社会信息的学习，并且这种增强将比非社会信息的处理更强。我们将进一步展示如何通过与学习相关的线索在睡眠期间操纵有关自己、他人或非社交计算机算法的信息重新激活来修改这些过程。最后，我们将揭示睡眠依赖的社会信息记忆巩固背后的神经机制。该项目的研究结果将为患有社会信息处理障碍的患者开辟基于睡眠的治疗新途径。自闭症谱系障碍、边缘性人格或社交焦虑症。