Genome-wide analysis of short RNAs as modulators in dehydration stress tolerance using tolerant and genetic model systems (ERA-PG 030)

使用耐受性和遗传模型系统对短 RNA 作为脱水应激耐受性调节剂进行全基因组分析 (ERA-PG 030)

• 批准号: 35899415
• 负责人: Professorin Dr. Dorothea Bartels
• 金额: --
• 依托单位: Abteilung Molekulare Physiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/35899415?language=en
• 关键词: Genome; wide; analysis; short; RNAs

The lack of understanding of drought tolerance mechanisms has impeded efforts to improve drought tolerance of crop plants. Production of the next generation of dehydration tolerant crops requires a better understanding of the molecular and genetic basis of dehydration tolerance. Our objective is to combine the expertise developed in German, Portuguese and UK laboratories to explore the roles of regulatory small 21-25nt RNAs (sRNAs) in dehydration tolerance using dehydration tolerant and genetic model systems. New families of stress associated sRNAs will be identified using innovative bioinformatics and high throughput genomics tools. The potential of these sRNAs will be characterised in transgenic plants. Our results will have important implications for gene regulation under dehydration stress, engineering stress tolerance and also contribute significantly to the long-term goal of having a comprehensive profile of sRNAs in different plant species.

对耐旱机制缺乏了解阻碍了提高作物耐旱性的努力。生产下一代耐脱水作物需要更好地了解耐脱水性的分子和遗传基础。我们的目标是结合德国、葡萄牙和英国实验室开发的专业知识，利用脱水耐受性和遗传模型系统探索调节性小 21-25nt RNA (sRNA) 在脱水耐受性中的作用。将使用创新的生物信息学和高通量基因组学工具来鉴定与应激相关的 sRNA 的新家族。这些 sRNA 的潜力将在转基因植物中得到表征。我们的结果将对脱水胁迫下的基因调控、工程胁迫耐受性产生重要影响，并且也对在不同植物物种中全面了解 sRNA 谱的长期目标做出重大贡献。